2-{[4-(3,4-二氯苄基)-2-吗啉基]甲基}-1H-异吲哚-1,3(2H)-二酮合成路线 (共 5 条)
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in propan-1-ol; toluene
Mitsunobu cyclisation;
参考文献
Wilkinson, Mark C.; Bell, Rebecca; Landon, Robert; Nikiforov, Petar O.; Walker, Andrew J.
Synlett, 2006 , # 13 p. 2151 - 2153
反应条件
1: in tetrahydrofuran
21.5 h; Heating / reflux;
2: With di-isopropyl azodicarboxylate; triphenylphosphine
T=7 - 22°C; 24.75 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2003/82834 A2, 2003 ;
Location in patent: Page/Page column 18 ;
WO 03/082834 A2
反应条件
1: toluene / 5 h / 122 °C
2: 101.5 g / PPh3; DIAD / toluene; propan-1-ol
View Scheme
参考文献
Wilkinson, Mark C.; Bell, Rebecca; Landon, Robert; Nikiforov, Petar O.; Walker, Andrew J.
Synlett, 2006 , # 13 p. 2151 - 2153
反应条件
1: toluene / 5 h / 122 °C
2: 101.5 g / PPh3; DIAD / toluene; propan-1-ol
View Scheme
参考文献
Wilkinson, Mark C.; Bell, Rebecca; Landon, Robert; Nikiforov, Petar O.; Walker, Andrew J.
Synlett, 2006 , # 13 p. 2151 - 2153
反应条件
1: toluene / 5 h / 122 °C
2: 101.5 g / PPh3; DIAD / toluene; propan-1-ol
View Scheme
参考文献
Wilkinson, Mark C.; Bell, Rebecca; Landon, Robert; Nikiforov, Petar O.; Walker, Andrew J.
Synlett, 2006 , # 13 p. 2151 - 2153