2,2-二甲基-4-氧代戊醛合成路线 （共 16 条）
反应条件
1: 95 percent / Hg(OAc)2 / 170 - 175 °C / in sealed tube
2: 1.) O3/O2, 2.) PPh3 / 1.) MeOH, CH2Cl2, -60 deg C, 2.) RT, 5 h
View Scheme
参考文献
Srikrishna, Adusumilli; Kumar, P. Praveen; Viswajanani, Ranganathan
Tetrahedron Letters, 1996 , vol. 37, # 10 p. 1683 - 1686
反应条件
1: 1) sodium hydroxide, 2) hydrochloric acid / 1) ethanol, water, 25 deg C, 3.5h, 2) water, 2h
2: 1) KOH, 2) potassium permanganate, magnesium sulphate / 1) methanol, 25 deg C, 2h, 2) water, 1h, pH= 7
View Scheme
参考文献
Lui, Kon-Hung; Sammes, Michael P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , p. 457 - 468
反应条件
(i) aq. HCl, THF (ii) Py*HClCrO3; Multistep reaction;
参考文献
Sato,T. et al.
Bulletin of the Chemical Society of Japan, 1977 , vol. 50, p. 2714 - 2730
反应条件
toluene-4-sulfonic acid in benzene
2.5 h; Heating;
参考文献
Iwata; Suzuki; Aoki; et al.
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 12 p. 4939 - 4946
反应条件
1: 93 percent / p-TsOH / benzene / 2.5 h / Heating
2: 89 percent / NaH / toluene / 12 h / Heating
3: 64.5 g / diazabicycloundecane / benzene / 12 h / 50 °C
4: 1.) NaOH; 2.) 50percent H2SO4 / 1.) water, 3 h, 60 deg C; 2.) 1 h, 50 deg C
View Scheme
参考文献
Iwata; Yamashita; Aoki; et al.
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 1 p. 436 - 439
反应条件
1: aq. KOH
2: NaOMe
View Scheme
参考文献
Stevens; Cherpeck; Harrison; Lai; Lapalme
Journal of the American Chemical Society, 1976 , vol. 98, # 20 p. 6317 - 6321
