2-(4-硝基苯基)-4,5-二氢-1H-咪唑合成路线 （共 15 条）
反应条件
sodium; oxalic acid 1.) C2H5OH, 0 deg C to 5 deg C, 40 min, 2.) reflux; Yield given. Multistep reaction;
参考文献
Shi, Zhen; Gu, Huan
Synthetic Communications, 1997 , vol. 27, # 15 p. 2701 - 2707
反应条件
oxygen; carbon in xylene T=120°C; 25 h;
参考文献
Haneda, Satoshi; Okui, Ayaka; Ueba, Chigusa; Hayashi, Masahiko
Tetrahedron, 2007 , vol. 63, # 11 p. 2414 - 2417
反应条件
iodine; potassium carbonate in tert-butyl alcohol
T=70°C; 3 h;
参考文献
Ishihara, Midori; Togo, Hideo
Tetrahedron, 2007 , vol. 63, # 6 p. 1474 - 1480
反应条件
1: (4-nitro-phenyl)-methanol With iodine; potassium carbonate in tert-butyl alcohol
T=70°C; 8 h;
2: ethylenediamine in tert-butyl alcohol
T=70°C; 2 h;
参考文献
Ishihara, Midori; Togo, Hideo
Tetrahedron, 2007 , vol. 63, # 6 p. 1474 - 1480
反应条件
1: (4-nitro-phenyl)-methanol With iodine; potassium carbonate in tert-butyl alcohol
Heating;
2: ethylenediamine in tert-butyl alcohol
Heating; Further stages.;
参考文献
Ren, Yi-Ming; Cai, Chun
Organic Preparations and Procedures International, 2008 , vol. 40, # 1 p. 101 - 105
参考文献
Shi, Zhen; Gu, Huan
Synthetic Communications, 1997 , vol. 27, # 15 p. 2701 - 2707
反应条件
1: 2-methyl-propan-2-ol / 20 °C
2: tert-butyl hypochlorite / 2-methyl-propan-2-ol / 2 h / 50 °C
View Scheme
参考文献
Ishihara, Midori; Togo, Hideo
Synthesis, 2007 , # 13 p. 1939 - 1942
反应条件
toluene-4-sulfonic acid
3 h; Refluxneat (no solvent);
参考文献
Nasr-Esfahani, Masoud; Montazerozohori, Morteza; Mehrizi, Safie
Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 2 p. 249 - 254
反应条件
1: PCl5 / benzene
2: 95 percent / benzene / 0.5 h / Heating
3: 98 percent / ethylenediamine / acetonitrile / 4 h / 20 °C
View Scheme
参考文献
Xia, Chizhong; Hao, Junsheng; Tang, Yiqing; Ni, Yanping; Zhou, Peiwen
Synthetic Communications, 2002 , vol. 32, # 9 p. 1457 - 1464
反应条件
1: PCl5 / benzene
2: 95 percent / benzene / 0.5 h / Heating
3: 98 percent / ethylenediamine / acetonitrile / 4 h / 20 °C
View Scheme
参考文献
Xia, Chizhong; Hao, Junsheng; Tang, Yiqing; Ni, Yanping; Zhou, Peiwen
Synthetic Communications, 2002 , vol. 32, # 9 p. 1457 - 1464
