3-氨基-N-Boc-L-丙氨酸甲酯合成路线 （共 14 条）
反应条件
hydrogen; palladium 10 on activated carbon in ethanol T=20°C; P=760.051 Torr; 1 h;
参考文献
Shetty, Dinesh; Jeong, Jae Min; Ju, Chang Hwan; Kim, Young Ju; Lee, Ji-Youn; Lee, Yun-Sang; Lee, Dong Soo; Chung, June-Key; Lee, Myung Chul
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 21 p. 7338 - 7347
反应条件
in methanol; diethyl ether; dichloromethane T=20°C; 2 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2007/93414 A1, 2007 ;
Location in patent: Page/Page column 55 ;
反应条件
hydrogen; palladium on activated charcoal in methanol T=20°C; P=760 Torr; 5 h;
参考文献
Couturier, Cedric; Blanchet, Jerome; Schlama, Thierry; Zhu, Jieping
Organic Letters, 2006 , vol. 8, # 10 p. 2183 - 2186
反应条件
diethylamine in methanol T=20°C; Inert atmosphere;
参考文献
Tosatti, Paolo; Horn, Joachim; Campbell, Amanda J.; House, David; Nelson, Adam; Marsden, Stephen P.
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 18 p. 3153 - 3157
反应条件
pyridine; bis-[(trifluoroacetoxy)iodo]benzene in N,N-dimethyl-formamide Hofmann rearrangement;
参考文献
Lherbet, Christian; Morin, Mylene; Castonguay, Roselyne; Keillor, Jeffrey W.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 6 p. 997 - 1000
反应条件
sodium tetrahydroborate; nickel dichloride in methanol T=-5°C; 0.416667 h; Inert atmosphere;
参考文献
Kumaraswamy, Gullapalli; Pitchaiah, Arigala
Helvetica Chimica Acta, 2011 , vol. 94, # 8 p. 1543 - 1550
反应条件
triethylamine in dichloromethane T=0°C; 1.5 h;
参考文献
Synthetic Communications, , vol. 23, # 5 p. 703 - 709
反应条件
hydrogen; palladium on activated charcoal in methanol Yield given;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 39, # 5 p. 1199 - 1212
反应条件
1: NaHCO3 / dioxane; H2O / 5 h / pH 8 - 9 2: H2 / Pd/C / methanol / 3 h View Scheme
参考文献
Organic Letters, , vol. 6, # 2 p. 213 - 215
反应条件
1: 73 percent / diethyl azodicarboxylate, hydrazoic acid, triphenylphosphine / tetrahydrofuran; benzene / Ambient temperature 2: 74 percent / H2 / Pd/C 10percent / methanol View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 33, # 2 p. 509 - 514
