2-氨基-3-硝基苯甲酸乙酯合成路线 （共 21 条）
反应条件
acetyl chloride in methanol; ethyl acetate
T=0 - 20°C; 64 h;
参考文献
S.I.M.S. S.r.l. - SOCIETA ITALIANA MEDICINALI SCANDICCI
Patent: WO2008/12852 A1, 2008 ;
Location in patent: Page/Page column 25; 38 ;
反应条件
sulfuric acid
240 h; Heating / reflux;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1479681 A1, 2004 ;
Location in patent: Page 106; 107 ;
反应条件
thionyl chloride
T=20°C; 15 h;
参考文献
Guillon, Jean; Le Borgne, Marc; Rimbault, Charlotte; Moreau, Stephane; Savrimoutou, Solene; Pinaud, Noel; Baratin, Sophie; Marchivie, Mathieu; Roche, Severine; Bollacke, Andre; Pecci, Adali; Alvarez, Lautaro; Desplat, Vanessa; Jose, Joachim
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 205 - 222
反应条件
caesium carbonate in N-methyl-acetamide; dichloromethane
参考文献
E. R. Squibb and Sons, Inc.
Patent: US5380719 A1, 1995 ;
反应条件
1: SOCl2 / 1 h / Heating
2: aq. NaN3 / acetone / 1 h / below 25 deg C
3: aq. AcOH / 0.17 h / Heating
View Scheme
参考文献
Denny, William A.; Rewcastle, Gordon W.; Baguley, Bruce C.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 814 - 819
反应条件
1: aq. NaN3 / acetone / 1 h / below 25 deg C
2: aq. AcOH / 0.17 h / Heating
View Scheme
参考文献
Denny, William A.; Rewcastle, Gordon W.; Baguley, Bruce C.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 814 - 819
反应条件
ammonia
T=130 - 150°C;
参考文献
Zacharias
Journal fuer Praktische Chemie (Leipzig), 1891 , vol. <2> 43, p. 444
Full Text Show Details
Huebner
Justus Liebigs Annalen der Chemie, 1879 , vol. 195, p. 37
Full Text Show Details
Huebner; Hall
Chemische Berichte, 1875 , vol. 8, p. 1216
反应条件
acetic acid
0.166667 h; Heating;
参考文献
Denny, William A.; Rewcastle, Gordon W.; Baguley, Bruce C.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 814 - 819
反应条件
T=130 - 140°C; im Druckrohr;
参考文献
Zacharias
Journal fuer Praktische Chemie (Leipzig), 1891 , vol. <2> 43, p. 444
Full Text Show Details
Huebner
Justus Liebigs Annalen der Chemie, 1879 , vol. 195, p. 37
反应条件
1: thionyl chloride / 3 h / |Reflux
2: thionyl chloride / 15 h / 20 °C
View Scheme
参考文献
Guillon, Jean; Le Borgne, Marc; Rimbault, Charlotte; Moreau, Stephane; Savrimoutou, Solene; Pinaud, Noel; Baratin, Sophie; Marchivie, Mathieu; Roche, Severine; Bollacke, Andre; Pecci, Adali; Alvarez, Lautaro; Desplat, Vanessa; Jose, Joachim
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 205 - 222
