diazomethyl-trimethyl-silane in toluene T=0 - 20°C; 0.916667 h;

in methanol; toluene T=0 - 20°C; 0.916667 h;

1: azetidine-3-carboxylic acid methyl ester hydrochloride; di-tert-butyl dicarbonate With sodium hydrogencarbonate in tetrahydrofuran; water T=0 - 20°C; 20 h; 2: di-tert-butyl dicarbonate With sodium hydrogencarbonate in tetrahydrofuran; water; ethyl acetate T=0 - 20°C; 60.5 h;

lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 1 h; Inert atmosphere;

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / -78 - 0 °C / Inert atmosphere 1.2: 0.5 h / -78 °C / Inert atmosphere 2.1: diisobutylaluminium hydride / toluene / -78 - 20 °C / Inert atmosphere 3.1: sodium tetrahydroborate / methanol / 1 h / 0 °C / Inert atmosphere 4.1: pyridine / 20 °C / Inert atmosphere View Scheme

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide; hexane / 0.67 h / -78 °C / Inert atmosphere 1.2: 0.5 h / -78 °C / Inert atmosphere 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere 2.2: 1.75 h / -78 - 20 °C / Inert atmosphere 3.1: diisobutylaluminium hydride / toluene / -78 °C / Inert atmosphere 4.1: pyridine; p-toluenesulfonyl chloride / 0 - 20 °C / Inert atmosphere 5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C / Inert atmosphere View Scheme

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide; hexane / 0.67 h / -78 °C / Inert atmosphere 1.2: 0.5 h / -78 °C / Inert atmosphere 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere 2.2: 1.75 h / -78 - 20 °C / Inert atmosphere 3.1: diisobutylaluminium hydride / toluene / -78 °C / Inert atmosphere 4.1: pyridine; p-toluenesulfonyl chloride / 0 - 20 °C / Inert atmosphere View Scheme

methyl-magnesium iodide in tetrahydrofuran T=20°C;