1-溴-4-氟-2-异丙氧基苯合成路线 （共 4 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=80°C; 8 h;
参考文献
Chiu, George; Li, Shengjian; Connolly, Peter J.; Pulito, Virginia L.; Liu, Jingchun; Middleton, Steven A.
Patent: US2006/217419 A1, 2006 ;
Location in patent: Page/Page column 35 ;
US 20060217419 A1
反应条件
potassium carbonate in acetone
24 h; Heating / reflux;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/73244 A1, 2005 ;
Location in patent: Page/Page column 16-17 ;
WO 2005/073244 A1
反应条件
sodium hydride in N,N-dimethyl-formamide
T=20°C; 8 h;
参考文献
Chiu, George; Li, Shengjian; Connolly, Peter J.; Pulito, Virginia; Liu, Jingchun; Middleton, Steven A.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 14 p. 3930 - 3934
反应条件
1: isopropyl alcohol With sodium hydride in tetrahydrofuran
T=0°C; 15 h;
2: 2,4-difluoro-1-bromobenzene in tetrahydrofuran
T=20°C; 17 h; Further stages.;
参考文献
Dirr, Ronan; Anthaume, Cyril; Desaubry, Laurent
Tetrahedron Letters, 2008 , vol. 49, # 31 p. 4588 - 4590
