1-苄基-4-[(4-氟苯基)氨基]哌啶-4-甲腈合成路线 （共 4 条）
反应条件
in acetic acid
T=20°C; 18 h;
参考文献
F.HOFFMANN-LA ROCHE AG
Patent: WO2005/40166 A1, 2005 ;
Location in patent: Page/Page column 35 ;
WO 2005/040166 A1
参考文献
Merrell Pharmaceuticals Inc.
Patent: US5635510 A1, 1997 ;
US 5635510 A
反应条件
acetic acid in water
T=0 - 20°C; Strecker reaction;
参考文献
Lavieri, Robert R.; Scott, Sarah A.; Selvy, Paige E.; Kim, Kwangho; Jadhav, Satyawan; Morrison, Ryan D.; Daniels, J. Scott; Brown, H. Alex; Lindsley, Craig W.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 18 p. 6706 - 6719
反应条件
sulfuric acid; sodium hydrogencarbonate in dichloromethane
参考文献
F.HOFFMANN-LA ROCHE AG
Patent: WO2005/40166 A1, 2005 ;
Location in patent: Page/Page column 35-36 ;
WO 2005/040166 A1
