1-苄基-4-(苯基氨基)哌啶-4-羧酸钠合成路线 （共 9 条）
反应条件
water; propionic acid anhydride in water; propionic acid anhydride T=70°C; 2 h; Heating / reflux;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1559428 A1, 2005 ;
Location in patent: Page/Page column 37 ;
EP 1559428 A1
反应条件
in dimethyl sulfoxide T=72°C; 0.166667 h;
参考文献
WO2008/5423 A1, ;
Page/Page column 3; 7 ;
反应条件
sodium hydroxide in N,N,N',N',N'',N''-hexamethylphosphoric triamide
反应条件
1: With potassium hydroxide; Propylene glycol
27 h; Heating / reflux;
2: With hydrogenchloride in water
T=5 - 10°C; pH=< 1;
3: With sodium hydroxide in water
pH=14;
参考文献
CAMBREX CHARLES CITY, INC.
Patent: WO2008/5423 A1, 2008 ;
Location in patent: Page/Page column 3; 6-7 ;
反应条件
sodium hydroxide
T=225°C; 18.5 h;
参考文献
Feldman; Brackeen
Journal of Organic Chemistry, 1990 , vol. 55, # 13 p. 4207 - 4209
反应条件
1: 81 percent / acetic acid / 0.5 h / T < 40 deg C
2: 100 percent / CH2Cl2 / 0.5 h / 20 - 30 °C
3: 60 percent / aq. HCl / 1 h / Heating
4: 82 percent / aq. sodium hydroxide / 18.5 h / 225 °C
View Scheme
参考文献
Feldman; Brackeen
Journal of Organic Chemistry, 1990 , vol. 55, # 13 p. 4207 - 4209
反应条件
1: 100 percent / CH2Cl2 / 0.5 h / 20 - 30 °C
2: 60 percent / aq. HCl / 1 h / Heating
3: 82 percent / aq. sodium hydroxide / 18.5 h / 225 °C
View Scheme
参考文献
Feldman; Brackeen
Journal of Organic Chemistry, 1990 , vol. 55, # 13 p. 4207 - 4209
反应条件
1: 81 percent / acetic acid / 0.5 h / T < 40 deg C
2: 100 percent / CH2Cl2 / 0.5 h / 20 - 30 °C
3: 60 percent / aq. HCl / 1 h / Heating
4: 82 percent / aq. sodium hydroxide / 18.5 h / 225 °C
View Scheme
参考文献
Feldman; Brackeen
Journal of Organic Chemistry, 1990 , vol. 55, # 13 p. 4207 - 4209
反应条件
1: 60 percent / aq. HCl / 1 h / Heating
2: 82 percent / aq. sodium hydroxide / 18.5 h / 225 °C
View Scheme
参考文献
Feldman; Brackeen
Journal of Organic Chemistry, 1990 , vol. 55, # 13 p. 4207 - 4209
