甲基 1-苄基-4-(苯基氨基)哌啶-4-羧酸合成路线 （共 17 条）
反应条件
in dimethyl sulfoxide T=72°C; 0.166667 h;
参考文献
WO2008/5423 A1, ;
Page/Page column 3; 7 ;
反应条件
triethylamine in acetonitrile T=20°C;
参考文献
US2010/99880 A1, ;
Page/Page column 8 ;
反应条件
sodium hydroxide in N,N,N',N',N'',N''-hexamethylphosphoric triamide
反应条件
1: 4-phenylamino-1-benzyl-4-piperidinecarboxylic acid With sodium hydride in N,N-dimethyl-formamide 2: methyl iodide in N,N-dimethyl-formamide T=20°C; 48 h;
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 24 p. 7720 - 7732
反应条件
sulfuric acid T=95°C; 16 h; Sealed tube;
参考文献
Tetrahedron Letters, , vol. 55, # 2 p. 501 - 502
反应条件
toluene-4-sulfonic acid T=105°C; 36 h;
参考文献
Journal of Organic Chemistry, , vol. 57, # 14 p. 4037 - 4038
反应条件
1.1: 77 percent / H2SO4 / 16 h / 20 °C 2.1: 76 percent / KOH / ethane-1,2-diol / 16 h / 190 °C 3.1: NaH / dimethylformamide 3.2: 42 percent / dimethylformamide / 48 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 24 p. 7720 - 7732
反应条件
1.1: 58 percent / aq. AcOH / 48 h / 20 °C 2.1: 77 percent / H2SO4 / 16 h / 20 °C 3.1: 76 percent / KOH / ethane-1,2-diol / 16 h / 190 °C 4.1: NaH / dimethylformamide 4.2: 42 percent / dimethylformamide / 48 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 24 p. 7720 - 7732
反应条件
1.1: 76 percent / KOH / ethane-1,2-diol / 16 h / 190 °C 2.1: NaH / dimethylformamide 2.2: 42 percent / dimethylformamide / 48 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 24 p. 7720 - 7732
反应条件
1.1: 58 percent / aq. AcOH / 48 h / 20 °C 2.1: 77 percent / H2SO4 / 16 h / 20 °C 3.1: 76 percent / KOH / ethane-1,2-diol / 16 h / 190 °C 4.1: NaH / dimethylformamide 4.2: 42 percent / dimethylformamide / 48 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 24 p. 7720 - 7732
