甲基 1-苄基-4-(苯基氨基)哌啶-4-羧酸合成路线 （共 17 条）
反应条件
1: 82 percent / aq. sodium hydroxide / 18.5 h / 225 °C 2: 58 percent / dimethylformamide / 90 deg C -> room temp. View Scheme
参考文献
Journal of Organic Chemistry, , vol. 55, # 13 p. 4207 - 4209
反应条件
1: 60 percent / aq. HCl / 1 h / Heating 2: 82 percent / aq. sodium hydroxide / 18.5 h / 225 °C 3: 58 percent / dimethylformamide / 90 deg C -> room temp. View Scheme
参考文献
Journal of Organic Chemistry, , vol. 55, # 13 p. 4207 - 4209
参考文献
Henriksen, Gjermund; Platzer, Stefan; Marton, Janos; Hauser, Andrea; Berthele, Achim; Schwaiger, Markus; Marinelli, Luciana; Lavecchia, Antonio; Novellino, Ettore; Wester, Hans-Juergen
Journal of Medicinal Chemistry, 2005 , vol. 48, # 24 p. 7720 - 7732
参考文献
Janssen Pharmaceutica N.V.
Patent: US4179569 A1, 1979 ;
反应条件
1: 23 percent / 6 h / Heating 2: 52 percent / H2 / Pd/C / ethanol / 24 h / 20 °C View Scheme
参考文献
Henriksen, Gjermund; Platzer, Stefan; Marton, Janos; Hauser, Andrea; Berthele, Achim; Schwaiger, Markus; Marinelli, Luciana; Lavecchia, Antonio; Novellino, Ettore; Wester, Hans-Juergen
Journal of Medicinal Chemistry, 2005 , vol. 48, # 24 p. 7720 - 7732
反应条件
1: With sodium bis(2-methoxyethoxy)aluminium dihydride in toluene
T=20°C; 2.25 h;
2: With sodium hydroxide; water in toluene
T=25 - 30°C;
参考文献
CAMBREX CHARLES CITY, INC.
Patent: WO2008/5423 A1, 2008 ;
Location in patent: Page/Page column 3; 8 ;
反应条件
sodium sulfate in toluene; benzene
参考文献
The BOC Group, Inc.
Patent: US4584303 A1, 1986 ;
