1-苄基-4-(苯氨基)哌啶-4 - 甲醇合成路线 （共 11 条）
反应条件
1: With sodium bis(2-methoxyethoxy)aluminium dihydride in toluene
T=20°C; 2.25 h;
2: With sodium hydroxide; water in toluene
T=25 - 30°C;
参考文献
CAMBREX CHARLES CITY, INC.
Patent: WO2008/5423 A1, 2008 ;
Location in patent: Page/Page column 3; 8 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=0°C; Inert atmosphereReflux;
参考文献
Srimurugan, Sankareswaran; Murugan, Kaliyappan; Chen, Chinpiao
Chemical and Pharmaceutical Bulletin, 2009 , vol. 57, # 12 p. 1421 - 1424
反应条件
lithium aluminium tetrahydride in tetrahydrofuran; dichloromethane
Ambient temperature;
参考文献
Colapret; Diamantidis; Spencer; Spaulding; Rudo
Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 968 - 974
反应条件
sodium sulfate in toluene; benzene
参考文献
The BOC Group, Inc.
Patent: US4584303 A1, 1986 ;
反应条件
in isopropyl alcohol; acetonitrile; benzene
参考文献
Janssen Pharmaceutica N.V.
Patent: US3998834 A1, 1976 ;
反应条件
1: conc. HCl / Heating
2: 80 percent / toluene / 240 h / Heating
3: 95 percent / LiAlH4 / tetrahydrofuran; CH2Cl2 / Ambient temperature
View Scheme
参考文献
Colapret; Diamantidis; Spencer; Spaulding; Rudo
Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 968 - 974
反应条件
2: H2SO4
3: conc. HCl / Heating
4: 80 percent / toluene / 240 h / Heating
5: 95 percent / LiAlH4 / tetrahydrofuran; CH2Cl2 / Ambient temperature
View Scheme
参考文献
Colapret; Diamantidis; Spencer; Spaulding; Rudo
Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 968 - 974
反应条件
1: H2SO4
2: conc. HCl / Heating
3: 80 percent / toluene / 240 h / Heating
4: 95 percent / LiAlH4 / tetrahydrofuran; CH2Cl2 / Ambient temperature
View Scheme
参考文献
Colapret; Diamantidis; Spencer; Spaulding; Rudo
Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 968 - 974
反应条件
2: H2SO4
3: conc. HCl / Heating
4: 80 percent / toluene / 240 h / Heating
5: 95 percent / LiAlH4 / tetrahydrofuran; CH2Cl2 / Ambient temperature
View Scheme
参考文献
Colapret; Diamantidis; Spencer; Spaulding; Rudo
Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 968 - 974
反应条件
1: 4-(N-phenylamino)-1-phenylmethyl-4-piperidinylmethanol With sodium hydride in tetrahydrofuran
T=20 - 50°C;
2: methyl iodide in tetrahydrofuran
T=0 - 20°C;
参考文献
Srimurugan, Sankareswaran; Murugan, Kaliyappan; Chen, Chinpiao
Chemical and Pharmaceutical Bulletin, 2009 , vol. 57, # 12 p. 1421 - 1424
