N-(1-苄基-4-(甲氧基甲基)哌啶-4-基)-N-苯基丙酰胺合成路线 (共 2 条)
反应条件
triethylamine in dichloromethane
T=0 - 20°C; 6.25 h;
参考文献
Srimurugan, Sankareswaran; Murugan, Kaliyappan; Chen, Chinpiao
Chemical and Pharmaceutical Bulletin, 2009 , vol. 57, # 12 p. 1421 - 1424
反应条件
1: With hydrogenchloride; hydrogen; acetic acid; palladium 10 on activated carbon in water
T=50°C; P=3102.97 Torr; 21 h;
2: With sodium hydroxide in water
T=0°C; pH=~ 13;
参考文献
CAMBREX CHARLES CITY, INC.
Patent: WO2008/5423 A1, 2008 ;
Location in patent: Page/Page column 4; 10 ;