N-[4-(甲氧基甲基)哌啶-4-基]-N-苯基丙酰胺合成路线 （共 5 条）
反应条件
potassium iodide; sodium carbonate in methanol; acetone
参考文献
Janssen Pharmaceutica, N.V.
Patent: US4167574 A1, 1979 ;
反应条件
potassium carbonate; triethylamine; potassium iodide in acetonitrile
4 h; Reflux;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2010/16365 A1, 2010 ;
Location in patent: Page/Page column 31 ;
US 20100016365 A1
反应条件
sodium carbonate in various solvent(s)
18 h; Heating;
参考文献
Janssens, Frans; Torremans, Joseph; Janssen, Paul A.J.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2290 - 2297
反应条件
hydrogenchloride in diethyl ether
0.5 h;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2010/16365 A1, 2010 ;
Location in patent: Page/Page column 26 ;
US 20100016365 A1
反应条件
potassium carbonate; triethylamine; potassium iodide in acetonitrile
T=20°C; Reflux;
参考文献
Srimurugan, Sankareswaran; Murugan, Kaliyappan; Chen, Chinpiao
Chemical and Pharmaceutical Bulletin, 2009 , vol. 57, # 12 p. 1421 - 1424
