2,5-双(苄氧基)苯甲醛合成路线 （共 7 条）
反应条件
1: 2,5-dihydroxy-benzaldehyde in ethylene glycol dimethyl ether T=80°C; Inert atmosphere; 2: benzyl bromide in ethylene glycol dimethyl ether; N,N-dimethyl-formamide 12 h;
参考文献
Galindo, Jose L.G.; MacIas, Mariola; Molinillo, Jose M.G.; Munoz-Suano, Alba; Torres, Ascension; Varela, Rosa M.; Garcia-Cozar, Francisco; MacIas, Francisco A.
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 22 p. 6662 - 6668
反应条件
potassium fluoride in N,N-dimethyl-formamide T=25°C; 2 h;
参考文献
Sinhababu, Achintya K.; Kawase, Masami; Borchardt, Ronald T.
Tetrahedron Letters, 1987 , vol. 28, # 36 p. 4139 - 4142
反应条件
sodium hydride in dimethyl sulfoxide
参考文献
WO2005/92326 A1, ;
Page/Page column 96; sheet 12 ;
反应条件
potassium carbonate in acetone T=20°C; 8 h; Schlenk techniqueGlovebox;
参考文献
Advanced Synthesis and Catalysis, , vol. 355, # 14-15 p. 2900 - 2907
反应条件
1.1: MgBr2(Et2O) / benzene; diethyl ether / |Inert atmosphere; |Reflux
2.1: potassium carbonate / acetonitrile / 60 h / |Reflux
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / |Inert atmosphere
4.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0 °C / |Inert atmosphere
4.2: 20 °C
5.1: hydrogen; palladium 10 on activated carbon / tetrahydrofuran / 20 °C / 2585.81 Torr / |Inert atmosphere
View Scheme
参考文献
THE UNIVERSITY OF NOTTINGHAM; MISTRY, Shailesh; DARAS, Etienne; FROMONT, Christophe; JADHAV, Gopal; FISCHER, Peter Martin; KELLAM, Barrie; HILL, Stephen John; BAKER, Jillian Glenda
Patent: WO2013/121209 A1, 2013 ;
反应条件
1: MgBr2(Et2O) / benzene; diethyl ether / |Inert atmosphere; |Reflux
2: potassium carbonate / acetonitrile / 60 h / |Reflux
3: hydrogen; palladium on activated charcoal / ethanol / 20 °C
View Scheme
参考文献
THE UNIVERSITY OF NOTTINGHAM; MISTRY, Shailesh; DARAS, Etienne; FROMONT, Christophe; JADHAV, Gopal; FISCHER, Peter Martin; KELLAM, Barrie; HILL, Stephen John; BAKER, Jillian Glenda
Patent: WO2013/121209 A1, 2013 ;
反应条件
magnesium bromide in diethyl ether; benzene
8 h; Heating;
参考文献
Hayashi, Ken-ichiro; Yamazoe, Atsushi; Ishibashi, Yuki; Kusaka, Naoyuki; Oono, Yutaka; Nozaki, Hiroshi
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 9 p. 5331 - 5344
