反应条件
1: methanol; aq. phosphate buffer / 60 °C / pH 6.4 2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C 3: trichloromonobromomethane; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 20 °C 4: potassium carbonate / acetone / |Reflux 5: lithium aluminium tetrahydride / tetrahydrofuran / -40 - -10 °C View Scheme
参考文献
Noel, Sabrina; Hoegy, Francoise; Rivault, Freddy; Rognan, Didier; Schalk, Isabelle J.; Mislin, Gaetan L.A.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 1 p. 132 - 135