2-甲基-1-苯基-1-丙醇合成路线 （共 136 条）
反应条件
N-ethyl-N,N-diisopropylamine; CF3-PIP in chloroform
T=0°C; 30 - 30.25 h; Resolution of racemate; Product distribution / selectivity;
参考文献
Birman, Vladimir
Patent: US2005/256150 A1, 2005 ;
Location in patent: Page/Page column 15; 16; 18 ;
反应条件
1: 1-hydroxy-2-(1-methyl)-propylbenzene With iPr2NCHEt2; (-)-Tetramisole in tetrahydrofuran
T=-78°C; 0.5 h; Molecular sieveInert atmosphereResolution of racemate;
2: triphenyl-silyl chloride in tetrahydrofuran
T=-78°C; 48 h; Inert atmosphereResolution of racemate; optical yield given as percent eeenantioselective reaction;
参考文献
Sheppard, Cody I.; Taylor, Jessica L.; Wiskur, Sheryl L.
Organic Letters, 2011 , vol. 13, # 15 p. 3794 - 3797
反应条件
1: 1-hydroxy-2-(1-methyl)-propylbenzene With (S,R(P))-2-phenyl-2,3-dihydroimidazo[1,2-a]pyrindinyl-pentaphenylcyclopentadienyliron; N-ethyl-N,N-diisopropylamine in toluene
T=0°C; 0.0833333 h;
2: propionic acid anhydride in toluene
T=0°C; 8 h; optical yield given as percent eeenantioselective reaction;
参考文献
Wang, Zheng; Ye, Jinjin; Wu, Rui; Liu, Yang-Zi; Fossey, John S.; Cheng, Jiagao; Deng, Wei-Ping
Catalysis Science and Technology, 2014 , vol. 4, # 7 p. 1909 - 1913
反应条件
(R)-7-chloro-2-phenyl-2,3-dihydroimidazo[1,2-a]quinoline; N-ethyl-N,N-diisopropylamine in chloroform
T=0°C; 8 h; Product distribution; Further Variations:Reagents;
参考文献
Birman, Vladimir B.; Li, Ximin
Organic Letters, 2006 , vol. 8, # 7 p. 1351 - 1354
反应条件
benzoic acid anhydride; N-ethyl-N,N-diisopropylamine in dichloromethane
T=20°C; 12 h; Title compound not separated from byproducts.;
参考文献
Shiina, Isamu; Nakata, Kenya
Tetrahedron Letters, 2007 , vol. 48, # 47 p. 8314 - 8317
反应条件
benzoic acid anhydride; N-ethyl-N,N-diisopropylamine in dichloromethane
T=20°C; 12 h; Title compound not separated from byproducts.;
参考文献
Shiina, Isamu; Nakata, Kenya
Tetrahedron Letters, 2007 , vol. 48, # 47 p. 8314 - 8317
反应条件
Birman's catalyst; trimethylacetic anhydride; N-ethyl-N,N-diisopropylamine in dichloromethane
T=20°C; 12 h; optical yield given as percent eeenantioselective reaction;
参考文献
Shiina, Isamu; Nakata, Kenya; Sugimoto, Masuhiro; Onda, Yu-Suke; Iizumi, Takashi; Ono, Keisuke
Heterocycles, 2009 , vol. 77, # 2 p. 801 - 810
反应条件
120 h; Ambient temperature; Product distribution;
参考文献
Potapov, V. M.; Dem'yanovich, V. M.; Khlebnikov, V. A.; Koval'skaya, S. S.
Journal of Organic Chemistry USSR (English Translation), 1985 , vol. 21, # 8 p. 1602 - 1606
Zhurnal Organicheskoi Khimii, 1985 , vol. 21, # 8 p. 1753 - 1758
反应条件
(i) (dehydration), (ii) /BRN= 102415/, CuCl; Multistep reaction;
参考文献
Kirmse,W. et al.
Chemische Berichte, 1966 , vol. 99, p. 2579 - 2592
反应条件
chloro-trimethyl-silane; dimethyl sulfoxide in acetonitrile
Heating;
参考文献
Bellesia, Franco; Ghelfi, Franco; Pagnoni, Ugo Maria; Pinetti, Adriano
Gazzetta Chimica Italiana, 1992 , vol. 122, # 10 p. 437 - 439
