2-甲基-1-苯基-1-丙醇合成路线 （共 136 条）
反应条件
(1R,2R,4S,5S)-4,8,8-triMe-2-Ph-2-phosphabicyclo[3.3.0]octane in toluene T=20°C; 1 h; Title compound not separated from byproducts;
参考文献
MacKay, James A.; Vedejs, Edwin
Journal of Organic Chemistry, 2006 , vol. 71, # 2 p. 498 - 503
反应条件
(R)-5-CF3-2-Ph-2,3-dihydroimidazo[1,2-a]pyridine; N-ethyl-N,N-diisopropylamine in chloroform 30 h; cooling; Title compound not separated from byproducts;
参考文献
Birman, Vladimir
Patent: US2005/256150 A1, 2005 ;
Location in patent: Page/Page column 15; 16; 18 ;
反应条件
Birman's catalyst; nicotinic anhydride in dichloromethane T=0°C; 12 h; Resolution of racemate; optical yield given as percent eeenantioselective reaction;
参考文献
Shiina, Isamu; Nakata, Kenya; Ono, Keisuke; Mukaiyama, Teruaki
Helvetica Chimica Acta, 2012 , vol. 95, # 10 p. 1891 - 1911,21
Title/Abstract Full Text Show Details
Shiina, Isamu; Nakata, Kenya; Ono, Keisuke; Mukaiyama, Teruaki
Helvetica Chimica Acta, 2012 , vol. 95, # 10 p. 1891 - 1911
反应条件
(R)-5-CF3-2-Ph-2,3-dihydroimidazo[1,2-a]pyridine; N-ethyl-N,N-diisopropylamine in chloroform T=0°C; 30 h; Title compound not separated from byproducts;
参考文献
Gleeson, Oliver; Gun'Ko, Yurii K.; Connon, Stephen J.
Synlett, 2013 , vol. 24, # 13 art. no. ST-2013-B0413-L, p. 1728 - 1734
反应条件
Birman's catalyst; trimethylacetic anhydride; N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 12 h; optical yield given as percent eeenantioselective reaction;
参考文献
Shiina, Isamu; Nakata, Kenya; Sugimoto, Masuhiro; Onda, Yu-Suke; Iizumi, Takashi; Ono, Keisuke
Heterocycles, 2009 , vol. 77, # 2 p. 801 - 810
反应条件
(1S,2R)-(+)-erythro-2-amino-1,2-diphenylethanol; benzoic acid in water; acetonitrile T=20°C;
参考文献
Kodama, Koichi; Sekine, Eriko; Hirose, Takuji
Chemistry - A European Journal, 2011 , vol. 17, # 41 p. 11527 - 11534
反应条件
N-ethyl-N,N-diisopropylamine; CF3-PIP in chloroform T=0°C; 30 - 30.25 h; Resolution of racemate; Product distribution / selectivity;
参考文献
Birman, Vladimir
Patent: US2005/256150 A1, 2005 ;
Location in patent: Page/Page column 15; 16; 18 ;
反应条件
1: 1-hydroxy-2-(1-methyl)-propylbenzene With iPr2NCHEt2; (-)-Tetramisole in tetrahydrofuran T=-78°C; 0.5 h; Molecular sieveInert atmosphereResolution of racemate; 2: triphenyl-silyl chloride in tetrahydrofuran T=-78°C; 48 h; Inert atmosphereResolution of racemate; optical yield given as percent eeenantioselective reaction;
参考文献
Sheppard, Cody I.; Taylor, Jessica L.; Wiskur, Sheryl L.
Organic Letters, 2011 , vol. 13, # 15 p. 3794 - 3797
反应条件
tertiary amine-based nucleophilic catalyst in 1,1-dimethylpropan-1-ol T=0°C; 17 h;
参考文献
Jeong, Kyu-Sung; Kim, Soong-Hyun; Park, Hyun-Jin; Chang, Kyoung-Jin; Kwan, Soo Kim
Chemistry Letters, 2002 , # 11 p. 1114 - 1115
反应条件
(R)-7-chloro-2-phenyl-2,3-dihydroimidazo[1,2-a]quinoline; N-ethyl-N,N-diisopropylamine in chloroform T=0°C; 8 h; Product distribution; Further Variations:Reagents;
参考文献
Birman, Vladimir B.; Li, Ximin
Organic Letters, 2006 , vol. 8, # 7 p. 1351 - 1354
