1: thiosemicarbazide; α-ketophenylacetic acid in water 0.25 h; Heating / reflux; 2: With potassium hydroxide in methanol; water T=80°C; 48 h; 3: methyl iodide in methanol; water T=40°C; 0.5 h;
参考文献
INCYTE CORPORATION
Patent: US2008/39457 A1, 2008 ;
Location in patent: Page/Page column 31 ;
US 20080039457 A1