N,N-二甲基苯甲酰胺合成路线 （共 319 条）
反应条件
ethanol; ammonia
T=-33°C; 0.166667 h;
参考文献
Schultz, Arthur G.; Macielag, Mark
Journal of Organic Chemistry, 1986 , vol. 51, # 25 p. 4983 - 4987
反应条件
1.1: LDA / heptane; tetrahydrofuran; ethylbenzene / 0.25 h / -80 °C
1.2: 82 percent / heptane; tetrahydrofuran; ethylbenzene / 3 h / -80 - 20 °C
2.1: 81 percent / NaBH4 / ethanol / 1.5 h / 20 °C
3.1: 98 percent / HCOOH / 23 h / Heating
4.1: aq. Na2CO3 / methanol / 2 h / 20 °C
5.1: 0.120 g / MnO2 / acetone / 24 h / 20 °C
View Scheme
参考文献
Broussy, Sylvain; Bernardes-Genisson, Vania; Gornitzka, Heinz; Bernadou, Jean; Meunier, Bernard
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 4 p. 666 - 669
反应条件
1: (i) POCl3, THF, (ii) aq. NaClO4
2: aq. NaOH / methanol
View Scheme
参考文献
Hafner,K.; Bangert,K.-F.
Justus Liebigs Annalen der Chemie, 1961 , vol. 650, p. 98 - 115
反应条件
copper diacetate; palladium diacetate; copper dichloride
T=120°C; 18 h; Neat (no solvent);
参考文献
Bedford, Robin B.; Engelhart, Jens U.; Haddow, Mairi F.; Mitchell, Charlotte J.; Webster, Ruth L.
Dalton Transactions, 2010 , vol. 39, # 43 p. 10464 - 10472
反应条件
n-butyllithium in tetrahydrofuran; hexane
T=30°C; 0.5 h;
参考文献
Verkruijsse, H. D.; Heus-Kloos, Y. A.; Brandsma, I.
Journal of Organometallic Chemistry, 1988 , vol. 338, p. 289 - 294
反应条件
1: alpha-chloropyridine With lithium diisopropyl amide
2: N,N-dimethyl benzamide in tetrahydrofuran
T=-78°C;
参考文献
Kobayashi, Kazuhiro; Suzuki, Teruhiko; Horiuchi, Mai; Shiroyama, Yasuhiko; Konishi, Hisatoshi
Synthesis, 2011 , # 18 art. no. F53211SS, p. 2897 - 2906
反应条件
1: 2,5-dibromo-pyridine With n-butyllithium in diethyl ether; hexane
T=-75°C; 0.5 h;
2: N,N-dimethyl benzamide in diethyl ether; hexane
0.583333 h;
参考文献
Gracel Display Inc.
Patent: US2009/62542 A1, 2009 ;
Location in patent: Page/Page column 11-12 ;
反应条件
1: 1.) phosphorus oxychloride / 1.) 1,2-dichloroethane, reflux, 0.75 h, 2.) reflux, 1 h
2: 1.) NaH / 1.) DMF, RT, 1 h, 2.) 55 deg C, 5 h
3: 85percent m-chloroperbenzoic acid / CH2Cl2 / 3 h / 0 °C
4: 95 percent / HCl / 0.5 h / Heating
5: 1.) NaH / 1.) DMF, RT, 2.) 85 deg C, 5 h
View Scheme
参考文献
Franco, Fidencio; Greenhouse, Robert; Muchowski, Joseph M.
Journal of Organic Chemistry, 1982 , vol. 47, # 9 p. 1682 - 1688
反应条件
(.eta.5-pentamethylcyclopentadienyl)(.eta.6-hexamethylbenzene)rhodium(I) in further solvent(s)
byproducts: H2; as solvent C6H5C(O)NEt2; at 150°C for 0.5 h; as mixt. of isomers;
参考文献
Cho; Iverson; Smith III
Journal of the American Chemical Society, 2000 , vol. 122, # 51 p. 12868 - 12869
反应条件
1.1: LDA / heptane; tetrahydrofuran; ethylbenzene / 0.25 h / -80 °C
1.2: 82 percent / heptane; tetrahydrofuran; ethylbenzene / 3 h / -80 - 20 °C
2.1: 81 percent / NaBH4 / ethanol / 1.5 h / 20 °C
3.1: 98 percent / HCOOH / 23 h / Heating
4.1: aq. Na2CO3 / methanol / 2 h / 20 °C
5.1: 0.120 g / MnO2 / acetone / 24 h / 20 °C
6.1: SOCl2 / 2.5 h / 60 °C
7.1: 120 mg / aq. NH4OH / acetone / 1.5 h / 20 °C
View Scheme
参考文献
Broussy, Sylvain; Bernardes-Genisson, Vania; Gornitzka, Heinz; Bernadou, Jean; Meunier, Bernard
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 4 p. 666 - 669
