4,4'-二羟基二苯甲酮合成路线 （共 99 条）
反应条件
sodium hydride in N,N-dimethyl-formamide; paraffin
1.) rt, 20 min; 50 deg C, 50 min; 2.) rt, overnight;
参考文献
Hahn, Wolfgang; Fredriksen, Siw Bodil; Dolle, Valerie; Nakatani, Yoichi; Ourisson, Guy
Bulletin de la Societe Chimique de France, 1997 , vol. 134, # 10,11 p. 915 - 926
反应条件
potassium hydroxide
T=20 - 100°C; 1 h;
参考文献
Sasse, Astrid; Ligneau, Xavier; Sadek, Bassem; Elz, Sigurd; Pertz, Heinz H.; Ganellin, C. Robin; Arrang, Jean-Michel; Schwartz, Jean-Charles; Schunack, Walter; Stark, Holger
Archiv der Pharmazie, 2001 , vol. 334, # 2 p. 45 - 52
反应条件
potassium carbonate in acetone
12 h; Heating;
参考文献
Mori, Tadashi; Inoue, Yoshihisa
Journal of Physical Chemistry A, 2005 , vol. 109, # 12 p. 2728 - 2740
反应条件
in tetrahydrofuran
silylation;
参考文献
Kim, Sung-Hoon; Katzenellenbogen, John A.
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 4 p. 785 - 793
参考文献
Liebermann
Chemische Berichte, 1873 , vol. 6, p. 953
参考文献
Staedel; Gail
Justus Liebigs Annalen der Chemie, 1878 , vol. 194, p. 334
反应条件
1: K2CO3; acetone
2: potassium tert-butylate; tert-butyl alcohol / Erwaermen des Reaktionsprodukts mit wss.-aethanol. KOH
View Scheme
参考文献
Baddar et al.
Journal of the Chemical Society, 1955 , p. 1714,1717
反应条件
potassium carbonate in methanol; chloroform
48 h; Heating;
参考文献
Dvornikovs, Vadims; House, Brian E.; Kaetzel, Marcia; Dedman, John R.; Smithrud, David B.
Journal of the American Chemical Society, 2003 , vol. 125, # 27 p. 8290 - 8301
反应条件
sodium hydride in N,N-dimethyl-formamide
T=50°C; 3.5 h;
参考文献
Ruenitz, Peter C.; Bourne, Caryl S.; Sullivan, Kelly J.; Moore, Susan A.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 24 p. 4853 - 4859
