4,4'-二羟基二苯甲酮合成路线 （共 99 条）
反应条件
sodium hydride in tetrahydrofuran 2 h;
参考文献
Journal of Organometallic Chemistry, , vol. 692, # 6 SPEC. ISS. p. 1219 - 1225
反应条件
sodium hydride in tetrahydrofuran
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 11 p. 4611 - 4618
反应条件
1: 88 percent / pyridine / 20 °C 2: 73 percent / aq. NaOH / methanol; tetrahydrofuran / 0.03 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 61, # 3 p. 609 - 616
反应条件
sodium hydride 1.) THF, mineral oil, room temperature, 30 min, 2.) THF, mineral oil, 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of Organic Chemistry, , vol. 61, # 11 p. 3890 - 3893
反应条件
1: 12 percent / K2CO3 / tetrahydrofuran / 4 h / Heating 2: 69 percent / TiCl4; Zn / tetrahydrofuran / Heating View Scheme
参考文献
Rubin, Valeria N; Ruenitz, Peter C; Boudinot; Boyd, Jason L
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 6 p. 1579 - 1587
反应条件
1: 4,4'-dihydroxy-benzophenone With potassium hydride in tetrahydrofuran; N,N-dimethyl-formamide 2: 1,4-dibromo-butane in tetrahydrofuran; N,N-dimethyl-formamide Further stages.;
参考文献
Jaouen; Top; Vessieres; Pigeon; Leclercq; Laios
Chemical Communications, 2001 , # 4 p. 383 - 384
反应条件
1.1: 91 percent / TiCl4; Zn / tetrahydrofuran / 2 h / Heating 2.1: Cs2CO3 / dimethylformamide / 0.17 h / 70 - 80 °C 2.2: dimethylformamide / 1.5 h / 70 - 80 °C View Scheme
参考文献
Gauthier, Sylvain; Mailhot, Josee; Labrie, Fernand
Journal of Organic Chemistry, 1996 , vol. 61, # 11 p. 3890 - 3893
反应条件
1: 87 percent / Li, TiCl3 / 1,2-dimethoxy-ethane / 1.) room temp., 4 h; 2.) reflux, 13 h 2: pyridine View Scheme
参考文献
Cid; Seijas; Villaverde; Castedo
Tetrahedron, 1988 , vol. 44, # 19 p. 6197 - 6200
反应条件
pyridine; potassium carbonate; copper(II) oxide T=150°C; Ullmann etherification; 168 h; Schlenk flask;
参考文献
Schreivogel, Alina; Maurer, Joerg; Winter, Rainer; Baro, Angelika; Laschat, Sabine
European Journal of Organic Chemistry, 2006 , # 15 p. 3395 - 3404
