2,4-二甲氧基-6-甲基苯甲酸甲酯合成路线 （共 29 条）
反应条件
potassium carbonate in acetone 24 h; Heating;
参考文献
Pulgarin, Cesar; Gunzinger, Jan; Tabacchi, Raffaele
Helvetica Chimica Acta, 1985 , vol. 68, p. 1948 - 1951
反应条件
potassium carbonate; dimethyl sulfate in diethyl ether; acetone
参考文献
Aventis Pharma S.A.
Patent: EP1300403 A1, 2003 ;
反应条件
potassium carbonate 12 h; Heating;
参考文献
Hashimoto, Toshihiro; Asakawa, Yoshinori
Heterocycles, 1998 , vol. 47, # 2 p. 1067 - 1110
反应条件
1: 1-bromo-2,4-dimethoxy-6-methylbenzene With n-butyllithium in tetrahydrofuran T=-78°C; 1 h; 2: methyl chloroformate in tetrahydrofuran T=-78 - 20°C;
参考文献
Mondal, Mukulesh; Puranik, Vedavati G.; Argade, Narshinha P.
Journal of Organic Chemistry, 2007 , vol. 72, # 6 p. 2068 - 2076
反应条件
sodium hydroxide in ethanol Heating;
参考文献
Wang, Ping; Zhang, Zhaojun; Yu, Biao
Journal of Organic Chemistry, 2005 , vol. 70, # 22 p. 8884 - 8889
反应条件
in diethyl ether T=0 - 5°C; 168 h;
参考文献
Jones, Graham B.; Huber, Robert S.; Chapman, Brant J.
Tetrahedron Asymmetry, 1997 , vol. 8, # 11 p. 1797 - 1809
反应条件
potassium carbonate in acetone 7 h; Inert atmosphereReflux;
参考文献
Arlt, Alexander; Koert, Ulrich
Synthesis, 2010 , # 6 p. 917 - 922
反应条件
1: 4.15 g / NaH2PO4; NaClO2 / dimethylsulfoxide; H2O / 20 °C 2: 77 percent / NaOH / ethanol / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 70, # 22 p. 8884 - 8889
反应条件
1.1: 99 percent / N-bromosuccinimide / CCl4 / 4 h / Heating 2.1: n-BuLi / tetrahydrofuran / 1 h / -78 °C 2.2: 96 percent / tetrahydrofuran / -78 - 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 72, # 6 p. 2068 - 2076
反应条件
sodium hydride in tetrahydrofuran Ambient temperature;
参考文献
Griffin, David A.; Leeper, Finian J.; Staunton, James
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 5 p. 1035 - 1042
