2,4-二甲氧基-6-甲基苯甲酸甲酯合成路线 （共 29 条）
反应条件
1: 99 percent / KOH / ethanol
2: LDA
3: K2CO3
View Scheme
参考文献
Fuerstner, Alois; Castanet, Anne-Sophie; Radkowski, Karin; Lehmann, Christian W.
Journal of Organic Chemistry, 2003 , vol. 68, # 4 p. 1521 - 1528
反应条件
lithium diisopropyl amide in tetrahydrofuran
T=-78°C;
参考文献
Hauser, Frank M.; Rhee, Richard P.; Prasanna, Subbarao; Weinreb, Steven M.; Dodd, John H.
Synthesis, 1980 , # 1 p. 72 - 74
反应条件
1: 2,4-dimethoxy-6-methylbenzoic acid methyl ester With lithium diisopropyl amide in tetrahydrofuran
T=-78°C;
2: 4-methoxy-6-methyl-2H-pyran-2-one in tetrahydrofuran
T=-78 - 20°C; Staunton-Weinreb annulation;
参考文献
Wadsworth, Andrew D.; Sperry, Jonathan; Brimble, Margaret A.
Synthesis, 2010 , # 15 art. no. P05810SS, p. 2604 - 2608
反应条件
1: 1.) lithium di-isopropylamide / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 1 h
2: 20 percent / lithium di-isopropylamide / tetrahydrofuran / 0.5 h / -15 °C
View Scheme
参考文献
Leeper, Finian J.; Staunton, James
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 5 p. 1053 - 1059
反应条件
dihydrogen peroxide; iodine in ethanol
参考文献
Drochner, Daniel; Huettel, Wolfgang; Bode, Silke E.; Mueller, Michael; Karl, Ulrich; Nieger, Martin; Steglich, Wolfgang
European Journal of Organic Chemistry, 2007 , # 11 p. 1749 - 1758
反应条件
1: 85 percent / I2, silver trifluoroacetate / CHCl3
2: 81 percent / copper bronze / 4.5 h / 200 °C
3: 73 percent / 48percent HBr, glacial acetic acid / 36 h / Heating
View Scheme
参考文献
Giles, Robin G. F.; Sargent, Melvyn V.
Australian Journal of Chemistry, 1986 , vol. 39, # 12 p. 2177 - 2181
反应条件
1.1: lithium diisopropylamide / tetrahydrofuran; hexane / 0.25 h / -78 °C
1.2: 69 percent / tetrahydrofuran; hexane / 0.83 h / -78 - 20 °C
2.1: 90 percent / potassium carbonate / 24 h / Heating
3.1: 74 percent / DIBAL-H / toluene / 3 h / -78 °C
4.1: 88 percent / sodium borohydride; trifluoroacetic acid / tetrahydrofuran / 1 h / 0 - 20 °C
5.1: 80 percent / 1,4-cyclohexadiene / Pd/C / ethanol; dioxane / 0.25 h / 20 °C
View Scheme
参考文献
Bulbule, Vivek J.; Koranne, Priti S.; Deshpande, Vishnu H.; Borate, Hanumant B.
Tetrahedron, 2007 , vol. 63, # 1 p. 166 - 170
反应条件
N-bromosuccinmide
1.) CCl4, reflux, 45 min, 2.) reflux, irradiation, 45 min; Yield given;
参考文献
Datta, Subhash C.; Franck, Richard W.; Noire, Paul D.
Journal of Organic Chemistry, 1984 , vol. 49, # 15 p. 2785 - 2791
反应条件
1: 98 percent / AlCl3 / CH2Cl2 / 0 - 20 °C
2: 72 percent / Ca(OH)2 / methanol / 72 h / 20 °C
3: 82 percent / KOH / methanol / 72 h / 20 °C
View Scheme
参考文献
Mondal, Mukulesh; Puranik, Vedavati G.; Argade, Narshinha P.
Journal of Organic Chemistry, 2007 , vol. 72, # 6 p. 2068 - 2076
