1-氮杂双环[3.3.1]壬烷-4-酮合成路线 （共 4 条）
反应条件
potassium tert-butylate in toluene
3 h; Heating;
参考文献
Kohn, Harold; Harden, T. Kendall; Kim, Myoung Goo; Bodor, Erik
Patent: US2004/29911 A1, 2004 ;
Location in patent: Page 9 ;
反应条件
hydrogenchloride
14 h; Heating;
参考文献
Kohn, Harold; Harden, T. Kendall; Kim, Myoung Goo; Bodor, Erik
Patent: US2004/29911 A1, 2004 ;
Location in patent: Page 9 ;
反应条件
1: 90 percent / 12 h / 80 °C
2: 33 percent / t-BuOK / toluene / 3 h / Heating
View Scheme
参考文献
Kim, Myoung Goo; Bodor, Erik T.; Wang, Chen; Harden, T. Kendall; Kohn, Harold
Journal of Medicinal Chemistry, 2003 , vol. 46, # 11 p. 2216 - 2226
反应条件
sodium tetrahydroborate in methanol
T=-10 - 0°C; 1 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2007/68476 A1, 2007 ;
Location in patent: Page/Page column 18-19 ;
