1-[(1,1-二甲基乙基)二甲基硅酯]-5-(3-氟苯基)-1H-吡咯并[2,3-B]吡啶合成路线 （共 2 条）
反应条件
1: 5-(3-fluoro-phenyl)-1H-pyrrolo[2,3-b]pyridine With n-butyllithium in tetrahydrofuran; 1,2,2-trichloro-1,1,2-trichloro-ethane
T=-78°C; 0.166667 h;
2: tert-butyldimethylsilyl chloride With 4-(N,N-dimethlyamino)pyridine in tetrahydrofuran; hexane
T=-78 - 20°C; 4 h;
参考文献
EISAI LONDON RESEARCH LABORATORIES LIMITED
Patent: WO2003/82868 A1, 2003 ;
Location in patent: Page/Page column 31; 35-36 ;
WO 03/082868 A1
反应条件
pyridine; bromine in tetrachloromethane; chloroform
T=0°C;
参考文献
EISAI LONDON RESEARCH LABORATORIES LIMITED
Patent: WO2003/82868 A1, 2003 ;
Location in patent: Page/Page column 31; 36 ;
WO 03/082868 A1
