1.1: 50 percent / methyltrioctylammonium chloride; NaOH / CH2Cl2; H2O / 0.5 h / -10 °C 2.1: butyllithium / tetrahydrofuran; hexane / 0.5 h / -5 °C 2.2: 80 percent / tetrahydrofuran; hexane; toluene / 1 h / -5 °C 3.1: lithium diisopropylamide / tetrahydrofuran; hexane / 0.5 h / 0 °C 3.2: tetrahydrofuran; hexane / 3 h / -78 °C 4.1: acetic acid / 3 h / Heating View Scheme

1.1: butyllithium / tetrahydrofuran; hexane / 0.5 h / -5 °C 1.2: 80 percent / tetrahydrofuran; hexane; toluene / 1 h / -5 °C 2.1: lithium diisopropylamide / tetrahydrofuran; hexane / 0.5 h / 0 °C 2.2: tetrahydrofuran; hexane / 3 h / -78 °C 3.1: acetic acid / 3 h / Heating View Scheme

1.1: lithium diisopropylamide / tetrahydrofuran; hexane / 0.5 h / 0 °C 1.2: tetrahydrofuran; hexane / 3 h / -78 °C 2.1: acetic acid / 3 h / Heating View Scheme

acetic acid 3 h; Heating;