(PYR6)-SUBSTANCE P (6-11)合成路线 （共 19 条）
反应条件
1: 70 percent / NMM, IBCF / dimethylformamide / -15 °C
2: 85 percent / 1N NaOH / dioxane; methanol / 0 deg C, 5 h, RT
3: 54.6 percent / IBCF, NMMole / dimethylformamide / -20 °C
4: TFA, anisole / CH2Cl2 / 1 h / 0 °C
5: 55 percent
View Scheme
参考文献
Michelot; Mayer; Magneney; Pham Van Chuong; Schmitt; Potier
European Journal of Medicinal Chemistry, 1988 , vol. 23, # 3 p. 243 - 247
反应条件
1: 93.6 percent / NMM, IBCF / dimethylformamide / -20 °C
2: TFA, anisole / CH2Cl2 / 1 h / 0 °C
3: 54.6 percent / IBCF, NMMole / dimethylformamide / -20 °C
4: TFA, anisole / CH2Cl2 / 1 h / 0 °C
5: 55 percent
View Scheme
参考文献
Michelot; Mayer; Magneney; Pham Van Chuong; Schmitt; Potier
European Journal of Medicinal Chemistry, 1988 , vol. 23, # 3 p. 243 - 247
反应条件
1: 70 percent / NMM, IBCF / dimethylformamide / -15 °C
2: 85 percent / 1N NaOH / dioxane; methanol / 0 deg C, 5 h, RT
3: 54.6 percent / IBCF, NMMole / dimethylformamide / -20 °C
4: TFA, anisole / CH2Cl2 / 1 h / 0 °C
5: 55 percent
View Scheme
参考文献
Michelot; Mayer; Magneney; Pham Van Chuong; Schmitt; Potier
European Journal of Medicinal Chemistry, 1988 , vol. 23, # 3 p. 243 - 247
反应条件
1: 54.6 percent / IBCF, NMMole / dimethylformamide / -20 °C
2: TFA, anisole / CH2Cl2 / 1 h / 0 °C
3: 55 percent
View Scheme
参考文献
Michelot; Mayer; Magneney; Pham Van Chuong; Schmitt; Potier
European Journal of Medicinal Chemistry, 1988 , vol. 23, # 3 p. 243 - 247
反应条件
1: 54.6 percent / IBCF, NMMole / dimethylformamide / -20 °C
2: TFA, anisole / CH2Cl2 / 1 h / 0 °C
3: 55 percent
View Scheme
参考文献
Michelot; Mayer; Magneney; Pham Van Chuong; Schmitt; Potier
European Journal of Medicinal Chemistry, 1988 , vol. 23, # 3 p. 243 - 247
反应条件
1: 85 percent / 1N NaOH / dioxane; methanol / 0 deg C, 5 h, RT
2: 54.6 percent / IBCF, NMMole / dimethylformamide / -20 °C
3: TFA, anisole / CH2Cl2 / 1 h / 0 °C
4: 55 percent
View Scheme
参考文献
Michelot; Mayer; Magneney; Pham Van Chuong; Schmitt; Potier
European Journal of Medicinal Chemistry, 1988 , vol. 23, # 3 p. 243 - 247
反应条件
1: TFA, anisole / CH2Cl2 / 1 h / 0 °C
2: 55 percent
View Scheme
参考文献
Michelot; Mayer; Magneney; Pham Van Chuong; Schmitt; Potier
European Journal of Medicinal Chemistry, 1988 , vol. 23, # 3 p. 243 - 247
反应条件
formic acid; palladium
1 h;
参考文献
Sivanandaiah, K. M.; Rangaraju, N. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 787 - 792
反应条件
water; palladium
1 h;
参考文献
Sivanandaiah, K. M.; Rangaraju, N. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 787 - 792
反应条件
1: Et3N / tetrahydrofuran
2: dimethylformamide; tetrahydrofuran / 10 h / -15 - 20 °C
3: Pd, H2O / 1 h
View Scheme
参考文献
Sivanandaiah, K. M.; Rangaraju, N. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 787 - 792
