8-氯-2-三氟甲基咪唑并[1,2-a]吡嗪合成路线 （共 4 条）
反应条件
N,N-dimethyl-aniline; trichlorophosphate
T=90°C; 5 h;
参考文献
Janssen Pharmaceutica NV
Patent: US2012/329792 A1, 2012 ;
Location in patent: Page/Page column 34 ;
反应条件
hydrogenchloride; water
T=90°C; 24 h;
参考文献
CARDIOME PHARMA CORPORATION
Patent: WO2005/34837 A2, 2005 ;
Location in patent: Page/Page column 43 ;
WO 2005/034837 A2
反应条件
in isopropyl alcohol
4 h; Heating / reflux;
参考文献
MERCK and CO., INC.
Patent: WO2003/82817 A2, 2003 ;
Location in patent: Page/Page column 54 ;
反应条件
1: methylmagnesium bromide With copper(I) bromide in tetrahydrofuran; diethyl ether
T=-78°C; 0.5 h;
2: 8-chloro-2-(trifluoromethyl)imidazo[1,2-a]pyrazine in tetrahydrofuran; diethyl ether
T=-78 - 20°C; 6 h;
参考文献
MERCK and CO., INC.
Patent: WO2003/82817 A2, 2003 ;
Location in patent: Page/Page column 54-55 ;
