3-苄氧基-2-甲基-4(1H)-吡啶酮合成路线 （共 9 条）
反应条件
ammonium hydroxide in ethanol 18 h; Heating;
参考文献
Dobbin; Hider; Hall; Taylor; Sarpong; Porter; Xiao; Van der Helm
Journal of Medicinal Chemistry, 1993 , vol. 36, # 17 p. 2448 - 2458
反应条件
1: 93 percent / aq. NaOH / methanol / 16 h / Heating 2: 58 percent / aq. NH3 / ethanol / 16 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 1 p. 43 - 50
反应条件
sodium hydroxide in methanol; water 6 h; Heating;
参考文献
Santos, M. Amelia; Gama, Sofia; Gano, Lurdes; Cantinho, Guilhermina; Farkas, Etelka
Dalton Transactions, 2004 , # 21 p. 3772 - 3781
反应条件
1.1: sodium hydroxide / methanol; water / Reflux 1.2: 6 h / Reflux 2.1: ammonia / ethanol / Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 19, # 3 p. 1285 - 1297
反应条件
1: 83 percent / sodium hydroxide / methanol; H2O / 6 h / Heating 2: 88 percent / 35 percent aq. ammonia / ethanol / 18 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 17 p. 2448 - 2458
反应条件
hydrogen bromide in acetic acid
参考文献
Nelson, William O.; Karpishin,Timothy B.; Rettig, Steven J.; Orvig, Cris
Canadian Journal of Chemistry, 1988 , vol. 66, p. 123 - 131
反应条件
1: Me3SiCl / 2 h / Heating
2: SnCl4 / 1,2-dichloro-ethane / 4 h / Ambient temperature
3: H2 / Pd/C / methanol; H2O; acetic acid
4: NH3/MeOH
View Scheme
参考文献
Liu; Bruenger; Barrios; Miller
Nucleosides and Nucleotides, 1995 , vol. 14, # 9-10 p. 1901 - 1904
反应条件
1: 1.) hexamethyldisilazane, ammonium sulfate, 2.) trimethylsilyl trifluoromethanesulfonate / 1.) reflux, 2 h, 2.) CH3CN, RT, 24 h
2: 0.98 g / H2 / Pd black / methanol / 760 Torr
View Scheme
参考文献
Mao, David T.; Driscoll, John S.; Marquez, Victor E.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 160 - 164
