1-(4-氯苯基)-3-羟基-4,5-二氢-1H-吡唑合成路线 （共 9 条）
反应条件
1: (4-chlorophenyl)hydrazine hydrochloride With ethanol; sodium in toluene T=40°C; 0.166667 h; Inert atmosphere; 2: acrylic acid methyl ester in ethanol; toluene 1.83333 h; Inert atmosphere;
参考文献
Mercader, Josep V.; Agullo, Consuelo; Abad-Somovilla, Antonio; Abad-Fuentes, Antonio
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 5 p. 1443 - 1453
反应条件
sodium ethanolate in ethanol; water; toluene
反应条件
1: ethyl acrylate With sodium methylate in ethanol; toluene T=40 - 45°C; 1 h; 2: (4-chlorophenyl)hydrazine hydrochloride in ethanol; toluene T=45°C; 15 h;
参考文献
European Journal of Organic Chemistry, , # 27 p. 5323 - 5330
反应条件
1.1: hydrogenchloride; sodium nitrite / water / 0.33 h / Cooling with ice 1.2: 2 h / -10 - -5 °C 2.1: sodium methylate / ethanol; toluene / 16 h / 40 - 45 °C View Scheme
参考文献
Bulletin of the Korean Chemical Society, , vol. 31, # 11 p. 3341 - 3347
参考文献
Journal of the Chemical Society, , p. 408,411
Journal of the Chemical Society, , p. 3470,3473
反应条件
ethanol; sodium ethanolate
参考文献
Ind. chim. belge Sonderband 27. Congr. int. Chim. ind. Bruessel 1954 Bd. 3, S. 602
反应条件
ethanol; sodium ethanolate
反应条件
1: With oxygen; copper(l) chloride in N,N-dimethyl-formamide T=20°C; 3 h; 2: With water in N,N-dimethyl-formamide 1 h;
参考文献
Mercader, Josep V.; Agullo, Consuelo; Abad-Somovilla, Antonio; Abad-Fuentes, Antonio
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 5 p. 1443 - 1453
反应条件
in potassium hydroxide
参考文献
BASF Aktiengesellschaft
Patent: US6040458 A1, 2000 ;
