5-羟基-1-甲基-5-吡啶-3-基-吡咯烷-2-酮合成路线 （共 9 条）
参考文献
Nguyen; Dagne; Gruenke; et al.
Journal of Organic Chemistry, 1981 , vol. 46, # 4 p. 758 - 760
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate
20 h;
参考文献
Nguyen; Dagne; Gruenke; et al.
Journal of Organic Chemistry, 1981 , vol. 46, # 4 p. 758 - 760
反应条件
trimethylsilyl iodide in chloroform
T=20°C; 24 h;
参考文献
Liu, Xin; Zang, Lunyi; Van Der Schyf, Cornells J.; Igarashi, Kazuo; Castagnoli, Kay; Castagnoli Jr., Neal
Chemical Research in Toxicology, 1999 , vol. 12, # 6 p. 508 - 512
反应条件
1: H2 / 10 percent Pd/C / methanol / 24 h / 20 °C / 735.51 Torr
2: 90 percent / trimethylsilyl iodide / CHCl3 / 24 h / 20 °C
View Scheme
参考文献
Liu, Xin; Zang, Lunyi; Van Der Schyf, Cornells J.; Igarashi, Kazuo; Castagnoli, Kay; Castagnoli Jr., Neal
Chemical Research in Toxicology, 1999 , vol. 12, # 6 p. 508 - 512
反应条件
1: 90 percent / KOH / -10 deg C, then 2 h room temperature
2: 82 percent / 15 percent aqueous HBr / 2 h / 95 °C
3: 92 percent / H2 / 10percent Pd/C / ethyl acetate / 20 h
View Scheme
参考文献
Nguyen; Dagne; Gruenke; et al.
Journal of Organic Chemistry, 1981 , vol. 46, # 4 p. 758 - 760
反应条件
phosphate buffer in water-d2
T=20°C; pH=7.4; 192 h; Product distribution;
参考文献
Liu, Xin; Zang, Lunyi; Van Der Schyf, Cornells J.; Igarashi, Kazuo; Castagnoli, Kay; Castagnoli Jr., Neal
Chemical Research in Toxicology, 1999 , vol. 12, # 6 p. 508 - 512
反应条件
diclazuril in water-d2
T=20°C; pH=1; 0.166667 h; Product distribution;
参考文献
Liu, Xin; Zang, Lunyi; Van Der Schyf, Cornells J.; Igarashi, Kazuo; Castagnoli, Kay; Castagnoli Jr., Neal
Chemical Research in Toxicology, 1999 , vol. 12, # 6 p. 508 - 512
反应条件
iodosylbenzene; (5,10,15,20-tetraphenylporphyrinato)manganese(III) chloride in dichloromethane
参考文献
Chauncey, M. A.; Ninomiya, Shin-ichi
Tetrahedron Letters, 1990 , vol. 31, # 41 p. 5901 - 5904
反应条件
diclazuril in water-d2
T=20°C; pH=1; 1.16667 h; Product distribution;
参考文献
Liu, Xin; Zang, Lunyi; Van Der Schyf, Cornells J.; Igarashi, Kazuo; Castagnoli, Kay; Castagnoli Jr., Neal
Chemical Research in Toxicology, 1999 , vol. 12, # 6 p. 508 - 512
