1,2,3,6,7,11B-六氢-4H-吡嗪并[2,1-Alpha]异喹啉-4-酮合成路线 （共 24 条）
反应条件
sulfuric acid in dichloromethane T=5°C; 3.5 h;
参考文献
Tang, Hui; Zheng, Can-Hui; Zhu, Ju; Fu, Bing-Yue; Zhou, You-Jun; Lv, Jia-Guo
Archiv der Pharmazie, 2010 , vol. 343, # 6 p. 360 - 366
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in methanol T=60°C; P=3420 Torr; 4 h;
参考文献
Yuste; Pallas; Barrios; et al.
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 1 p. 189 - 190
反应条件
1: With hydrogenchloride; water 24 h; Reflux; 2: With sodium hydroxide in water regioselective reaction;
参考文献
Dong, Yuxiang; Chollet, Jacques; Vargas, Mireille; Mansour, Nuha R.; Bickle, Quentin; Alnouti, Yazen; Huang, Jiangeng; Keiser, Jennifer; Vennerstrom, Jonathan L.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 8 p. 2481 - 2484
反应条件
sulfuric acid in dichloromethane T=10 - 30°C; 2.5 h; Large scale;
参考文献
BALAYA, Lingappa; MANJATHURU, Mahalinga; DERAMBALA, Yogeesh; VASUDEVA, Pejakala Kakrannaya; ARULMOLI, Thangavel
Patent: US2013/289275 A1, 2013 ;
Location in patent: Paragraph 0056; 0057; 0058 ;
反应条件
1: polyphosphoric acid / 180 °C 2: H2 / Pd-C / ethanol / 45 °C / 760 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 9 p. 2058 - 2062
反应条件
1: NaBH4, NaHCO3 / ethanol; H2O / 5 °C 2: polyphosphoric acid / 180 °C 3: H2 / Pd-C / ethanol / 45 °C / 760 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 9 p. 2058 - 2062
反应条件
1: Heating 2: NaBH4, NaHCO3 / ethanol; H2O / 5 °C 3: polyphosphoric acid / 180 °C 4: H2 / Pd-C / ethanol / 45 °C / 760 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 9 p. 2058 - 2062
反应条件
1.1: toluene / Reflux 1.2: -30 °C 2.1: sulfuric acid / dichloromethane / 3.5 h / 5 °C View Scheme
参考文献
Archiv der Pharmazie, , vol. 343, # 6 p. 360 - 366
反应条件
1: hydrogen / methanol / 20 h / 25 - 67 °C / 7500.75 Torr / |Inert atmosphere; |Large scale 2: sulfuric acid / dichloromethane / 2.5 h / 10 - 30 °C / |Large scale View Scheme
反应条件
1: 1.) CH3ONa / 1.) DMF, RT, 1 h, 2.) DMF, 120 deg C, 6 h 2: 1.) CuCl2*2H2O, 2.) NaBH4 / 1.) ethanol, 0 deg C, 1 h, 2.) ethanol, 0 deg C 45 min. 3: 94 percent / 12N HCl / 0 °C 4: 1N HCl / 3 h / Heating View Scheme
参考文献
Heterocycles, , vol. 20, # 9 p. 1731 - 1735
