反应条件
1.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 0.33 h / 0 - 20 °C 2.1: sodium hydroxide; water / N,N-dimethyl-formamide / 36 h / 20 °C 3.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 0.08 h / 0 - 20 °C 4.1: potassium phosphate; ethanol / 10 h / 70 °C 5.1: sodium hydride / ethylene glycol dimethyl ether / 0.17 h / 0 °C / |Schlenk technique 5.2: 1 h / 20 °C / |Schlenk technique 6.1: potassium phosphate; palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl / tert-butyl alcohol / 12 h / 90 °C / |Inert atmosphere; |Schlenk technique 7.1: Ni(PCy3)2Cl2; tri-cyclo-hexyl-phosphine; potassium carbonate / 1,4-dioxane / 24 h / 120 °C / |Inert atmosphere; |Schlenk technique 8.1: Ni(PCy3)2Cl2 / toluene / 24 h / 130 °C / |Inert atmosphere; |Schlenk technique View Scheme
参考文献
Organic Letters, , vol. 15, # 13 p. 3230 - 3233
