4,5-二甲氧基-2-碘苯甲酸合成路线 （共 14 条）
反应条件
1.1: thionyl chloride / toluene; N,N-dimethyl-formamide / 2.92 h / 0 - 80 °C / |Inert atmosphere
2.1: triethylamine / dichloromethane / 0.08 h / 0 °C / |Inert atmosphere
2.2: 0 - 20 °C / |Inert atmosphere
3.1: 1,10-phenanthroline; potassium tert-butylate / 1,3,5-trimethyl-benzene / 6 h / 100 °C / |Inert atmosphere
View Scheme
参考文献
De, Subhadip; Ghosh, Santanu; Bhunia, Subhajit; Sheikh, Javeed Ahmad; Bisai, Alakesh
Organic Letters, 2012 , vol. 14, # 17 p. 4466 - 4469
反应条件
1: oxalyl chloride / CH2Cl2 / 4 h / Heating
2: 1.44 g / Et3N / CH2Cl2 / 16 h / Heating
3: 35 percent / Pd(OAc)2; P(o-tolyl)3; Ag2CO3 / dimethylformamide / 0.5 h / Heating
4: 95 percent / formic acid; AcOH / Pd black / 1.5 h / 20 °C
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参考文献
Ruchelman, Alexander L.; Houghton, Peter J.; Zhou, Nai; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 3 p. 792 - 804
反应条件
1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 0 - 20 °C
2: pyridinium chlorochromate; silica gel / dichloromethane / 2 h / 0 - 20 °C
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参考文献
Zhou, Ping-Xin; Luo, Jian-Yi; Zhao, Lian-Biao; Ye, Yu-Ying; Liang, Yong-Min
Chemical Communications, 2013 , vol. 49, # 31 p. 3254 - 3256
反应条件
1: oxalyl chloride / dimethylformamide; CH2Cl2 / 1.5 h / Heating
2: 2.08 g / NEt3 / CH2Cl2 / 1 h / Ambient temperature
3: 96.4 percent / NaH / dimethylformamide / 0.5 h / Ambient temperature
4: 89 percent / tris(2-methylphenyl)phosphine, silver carbonate / Pd(OAc)2 / dimethylformamide / 2 h / Heating
View Scheme
参考文献
Lv, Pei; Huang, Kanglun; Xie, Longguan; Xu, Xiaohua
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 9 p. 3133 - 3135
