2-碘-4,5-二甲氧基苯甲醛合成路线 （共 22 条）
反应条件
sodium tetrahydroborate in isopropyl alcohol 12 h; Heating;
参考文献
Coltart, Don M.; Charlton, James L.
Canadian Journal of Chemistry, 1996 , vol. 74, # 1 p. 88 - 94
反应条件
1.1: n-BuLi / tetrahydrofuran / 0.5 h / 0 °C 1.2: 90 percent / tetrahydrofuran 2.1: 82 percent / Pd(OAc)2; pyridine; n-Bu4NCl / dimethylformamide / 24 h / 100 °C / 760 Torr View Scheme
参考文献
Gagnier, Steve V.; Larock, Richard C.
Journal of the American Chemical Society, 2003 , vol. 125, # 16 p. 4804 - 4807
反应条件
sodium chlorite; sodium dihydrogenphosphate; dihydrogen peroxide in water; acetonitrile T=10°C; 5 h;
参考文献
Heterocycles, , vol. 49, # 1 p. 191 - 195
反应条件
1.1: dihydrogen peroxide; potassium hydroxide / methanol; water / 0.5 h / 65 °C / Inert atmosphere 2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / Inert atmosphere 3.1: 0.5 h / Inert atmosphere 4.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine; zinc(II) chloride; zinc / tetrahydrofuran / 24 h / 60 °C / Inert atmosphere 5.1: potassium hydroxide / aacetone / 2 h / Reflux; Inert atmosphere 6.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / benzene / 2 h / Inert atmosphere; Reflux 7.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere 7.2: 20 °C View Scheme
参考文献
Lv, Pei; Huang, Kanglun; Xie, Longguan; Xu, Xiaohua
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 9 p. 3133 - 3135
反应条件
1: dihydrogen peroxide; potassium hydroxide / methanol; water / 0.5 h / 65 °C / Inert atmosphere 2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / Inert atmosphere 3: 0.5 h / Inert atmosphere View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 9, # 9 p. 3133 - 3135
反应条件
1: 98 percent / sodium phosphate monobasic dihydrate, 35 percent hydrogen peroxide, sodium chlorite / acetonitrile; H2O / 5 h / 10 °C 2: oxalyl chloride / dimethylformamide; CH2Cl2 / 1.5 h / Heating View Scheme
参考文献
Lv, Pei; Huang, Kanglun; Xie, Longguan; Xu, Xiaohua
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 9 p. 3133 - 3135
反应条件
iodine; silver sulphate in ethanol
T=20°C; 3 h; Inert atmosphere;
参考文献
FIBROTECH THERAPEUTICS PTY LTD; WILLIAMS, Spencer John; ZAMMIT, Steven; KELLY, Darren James
Patent: WO2011/47432 A1, 2011 ;
Location in patent: Page/Page column 92-93 ;
反应条件
manganese(IV) oxide in dichloromethane
1008 h; Ambient temperature;
参考文献
Olivera, Roberto; SanMartin, Raul; Dominguez, Esther; Solans, Xabier; Urtiaga, Miren Karmele; Arriortua, Maria Isabel
Journal of Organic Chemistry, 2000 , vol. 65, # 20 p. 6398 - 6411
反应条件
n-butyllithium; iodine; acetic acid in tetrahydrofuran; ethyl acetate
参考文献
Tanabe Seiyaku Co., Ltd.
Patent: US5103023 A1, 1992 ;
反应条件
1: 91 percent / I2; AgOCOCF3 / CHCl3 / 2 h / 20 °C
2: 95 percent / PDC / CH2Cl2 / 0.75 h / 0 °C
View Scheme
参考文献
Olivera, Roberto; SanMartin, Raul; Dominguez, Esther; Solans, Xabier; Urtiaga, Miren Karmele; Arriortua, Maria Isabel
Journal of Organic Chemistry, 2000 , vol. 65, # 20 p. 6398 - 6411
