2-碘-4,5-二甲氧基苯甲醛合成路线 （共 22 条）
反应条件
1: 99 percent / H2O; AgNO3 / acetone / 1 h / 20 °C
2: 95 percent / PDC / CH2Cl2 / 0.75 h / 0 °C
View Scheme
参考文献
Olivera, Roberto; SanMartin, Raul; Dominguez, Esther; Solans, Xabier; Urtiaga, Miren Karmele; Arriortua, Maria Isabel
Journal of Organic Chemistry, 2000 , vol. 65, # 20 p. 6398 - 6411
反应条件
1: p-toluenesulfonic acid hydrate / benzene / 5 h / Heating
2: 1.) n-butyllithium, 2.) iodine / 1.) THF, 15 min, 2.) THF, 15 min
View Scheme
参考文献
Coltart, Don M.; Charlton, James L.
Canadian Journal of Chemistry, 1996 , vol. 74, # 1 p. 88 - 94
反应条件
1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 0 - 20 °C
2: pyridinium chlorochromate; silica gel / dichloromethane / 2 h / 0 - 20 °C
View Scheme
参考文献
Zhou, Ping-Xin; Luo, Jian-Yi; Zhao, Lian-Biao; Ye, Yu-Ying; Liang, Yong-Min
Chemical Communications, 2013 , vol. 49, # 31 p. 3254 - 3256
反应条件
1.1: sodium nitrite; hydrogenchloride / water / 1 h / 0 °C
1.2: 0 - 90 °C
2.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 0 - 20 °C
3.1: pyridinium chlorochromate; silica gel / dichloromethane / 2 h / 0 - 20 °C
View Scheme
参考文献
Zhou, Ping-Xin; Luo, Jian-Yi; Zhao, Lian-Biao; Ye, Yu-Ying; Liang, Yong-Min
Chemical Communications, 2013 , vol. 49, # 31 p. 3254 - 3256
反应条件
1: sodium sulfide; alcohol
2: diluted alkaline solution
3: nach Sandmeyer
View Scheme
参考文献
Rilliet
Helvetica Chimica Acta, 1922 , vol. 5, p. 548
反应条件
2: sodium sulfide; alcohol
3: diluted alkaline solution
4: nach Sandmeyer
View Scheme
参考文献
Rilliet
Helvetica Chimica Acta, 1922 , vol. 5, p. 548
参考文献
Rilliet
Helvetica Chimica Acta, 1922 , vol. 5, p. 548
反应条件
cesium fluoride; tris-(o-tolyl)phosphine; bis(dibenzylideneacetone)-palladium(0) in toluene; acetonitrile
T=110°C; 12 h;
参考文献
Waldo, Jesse P.; Zhang, Xiaoxia; Shi, Feng; Larock, Richard C.
Journal of Organic Chemistry, 2008 , vol. 73, # 17 p. 6679 - 6685
反应条件
copper
T=230 - 240°C; 0.25 h;
参考文献
Sanceau, Jean-Yves; Dhal, Robert; Brown, Eric
Tetrahedron, 1994 , vol. 50, # 11 p. 3363 - 3380
反应条件
2: 1.) sec-BuLi, N,N,N',N'-tetramethylethylenediamine, CuI-P(EtO)3 / 1.) ether, cyclohexane, -50 to -40 deg C, 2 h; -45 deg C, 30 min, 2.) r.t., 18 h
3: 1 M aq. HCl / tetrahydrofuran / 0.5 h / Heating
4: HCl / CHCl3 / 0.25 h / Ambient temperature
View Scheme
参考文献
Parnes; Carter; Kurz; Flippin
Journal of Organic Chemistry, 1994 , vol. 59, # 12 p. 3497 - 3499
