1: 89 percent / sodium borohydride / tetrahydrofuran; aq. NaOH / 0.25 h / Ambient temperature 2: dimethylformamide / 0.5 h / 110 °C 3: potassium hydroxyde / H2O; methanol / Heating View Scheme

1: 98 percent / sodium phosphate monobasic dihydrate, 35 percent hydrogen peroxide, sodium chlorite / acetonitrile; H2O / 5 h / 10 °C 2: oxalyl chloride / dimethylformamide; CH2Cl2 / 1.5 h / Heating 3: 2.08 g / NEt3 / CH2Cl2 / 1 h / Ambient temperature 4: 96.4 percent / NaH / dimethylformamide / 0.5 h / Ambient temperature 5: 89 percent / tris(2-methylphenyl)phosphine, silver carbonate / Pd(OAc)2 / dimethylformamide / 2 h / Heating View Scheme