4-(反-4-戊基环己基)苯甲腈合成路线 （共 18 条）
反应条件
1: hydrazine hydrate / bis-(2-hydroxy-ethyl) ether / or in 1:1 mixture of triethanolamine and glycerol 2: AlCl3 / 1,2-dichloro-ethane / 0.5 h 3: aq. NaOH, Br2 / dioxane / 3 h / 35 - 40 °C 4: SOCl2 / 1 h / Heating 5: 25percent aq. NH4OH 6: 62 percent / SOCl2, dimethylformamide / 1.5 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 19, p. 1479 - 1483
Zhurnal Organicheskoi Khimii, , vol. 19, # 8 p. 1669 - 1674
反应条件
1: AlCl3 / 4 h / 45 - 50 °C 2: 80 percent NH2NH2, KOH / bis-(2-hydroxy-ethyl) ether / 1 h / Heating 3: AlCl3 / 3 h / 0 °C 4: Br2 / dioxane / 5 h 5: 1) SOCl2; 2) 25 percent aq. NH3 / 1) DMF, reflux, 2.5 h; 2) DMF, dioxane 6: SOCl2 / dimethylformamide / 3 h / 80 °C View Scheme
参考文献
Molecular crystals and liquid crystals, , vol. 88, # 1-4 p. 55 - 64
反应条件
1: 80 percent NH2NH2, KOH / bis-(2-hydroxy-ethyl) ether / 1 h / Heating 2: AlCl3 / 3 h / 0 °C 3: Br2 / dioxane / 5 h 4: 1) SOCl2; 2) 25 percent aq. NH3 / 1) DMF, reflux, 2.5 h; 2) DMF, dioxane 5: SOCl2 / dimethylformamide / 3 h / 80 °C View Scheme
参考文献
Molecular crystals and liquid crystals, , vol. 88, # 1-4 p. 55 - 64
反应条件
1: 25percent aq. NH4OH 2: 62 percent / SOCl2, dimethylformamide / 1.5 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 19, p. 1479 - 1483
Zhurnal Organicheskoi Khimii, , vol. 19, # 8 p. 1669 - 1674
反应条件
hydrogenchloride in diethyl ether Ambient temperature;
参考文献
Liang, Jason C.; Cross, Julie O.
Molecular Crystals and Liquid Crystals (1969-1991), 1986 , vol. 132, p. 123 - 130
反应条件
magnesium in tetrahydrofuran; diethyl ether 5 h; Heating; Yield given;
参考文献
Osman; Huynh-Ba
Molecular crystals and liquid crystals, 1984 , vol. 116, # 1-2 p. 141 - 152
反应条件
sulfuric acid; acetic acid T=120°C;
参考文献
Kelly, Stephen M.; Buchecker, Richard
Helvetica Chimica Acta, 1988 , vol. 71, p. 451 - 460
反应条件
1: sulfuric acid, water / 5 h / Heating
2: lithium aluminum hydride / tetrahydrofuran / Ambient temperature
View Scheme
参考文献
Liang, J. C.; Chen, L.
Molecular Crystals and Liquid Crystals (1969-1991), 1989 , vol. 167, p. 253 - 258
