反式-4-(4-庚基环己基)苯腈合成路线 （共 11 条）
反应条件
thionyl chloride; N,N-dimethyl-formamide 1.5 h; Ambient temperature;
参考文献
Bezborodov, V. S.; Bubel', O. N.; Konovalov, V. A.; Ptashnikov, Yu. L.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, p. 1479 - 1483
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 8 p. 1669 - 1674
反应条件
1: 2.) 10percent aq. HCl / 1.) diethyl ether, 1 h, heating 2: p-toluenesulfonic acid / toluene / Heating 3: H2 / 10percent Pd/C / ethanol 4: AlCl3 / 1,2-dichloro-ethane / 0.5 h 5: aq. NaOH, Br2 / dioxane / 3 h / 35 - 40 °C 6: SOCl2 / 1 h / Heating 7: 25percent aq. NH4OH 8: 64 percent / SOCl2, dimethylformamide / 1.5 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 19, p. 1479 - 1483
Zhurnal Organicheskoi Khimii, , vol. 19, # 8 p. 1669 - 1674
反应条件
1: H2 / 10percent Pd/C / ethanol 2: AlCl3 / 1,2-dichloro-ethane / 0.5 h 3: aq. NaOH, Br2 / dioxane / 3 h / 35 - 40 °C 4: SOCl2 / 1 h / Heating 5: 25percent aq. NH4OH 6: 64 percent / SOCl2, dimethylformamide / 1.5 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 19, p. 1479 - 1483
Zhurnal Organicheskoi Khimii, , vol. 19, # 8 p. 1669 - 1674
反应条件
1: p-toluenesulfonic acid / toluene / Heating 2: H2 / 10percent Pd/C / ethanol 3: AlCl3 / 1,2-dichloro-ethane / 0.5 h 4: aq. NaOH, Br2 / dioxane / 3 h / 35 - 40 °C 5: SOCl2 / 1 h / Heating 6: 25percent aq. NH4OH 7: 64 percent / SOCl2, dimethylformamide / 1.5 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 19, p. 1479 - 1483
Zhurnal Organicheskoi Khimii, , vol. 19, # 8 p. 1669 - 1674
反应条件
1: SOCl2 / 1 h / Heating 2: 25percent aq. NH4OH 3: 64 percent / SOCl2, dimethylformamide / 1.5 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 19, p. 1479 - 1483
Zhurnal Organicheskoi Khimii, , vol. 19, # 8 p. 1669 - 1674
反应条件
1: aq. NaOH, Br2 / dioxane / 3 h / 35 - 40 °C 2: SOCl2 / 1 h / Heating 3: 25percent aq. NH4OH 4: 64 percent / SOCl2, dimethylformamide / 1.5 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 19, p. 1479 - 1483
Zhurnal Organicheskoi Khimii, , vol. 19, # 8 p. 1669 - 1674
反应条件
1: AlCl3 / 1,2-dichloro-ethane / 0.5 h 2: aq. NaOH, Br2 / dioxane / 3 h / 35 - 40 °C 3: SOCl2 / 1 h / Heating 4: 25percent aq. NH4OH 5: 64 percent / SOCl2, dimethylformamide / 1.5 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 19, p. 1479 - 1483
Zhurnal Organicheskoi Khimii, , vol. 19, # 8 p. 1669 - 1674
反应条件
1: AlCl3 / 4 h / 45 - 50 °C 2: 80 percent NH2NH2, KOH / bis-(2-hydroxy-ethyl) ether / 1 h / Heating 3: 24.1 percent / AlCl3 / CH2Cl2 / 3 h / 0 °C 4: 88.9 percent / Br2, NaOH / dioxane / 5 h 5: 1) SOCl2; 2) 25 percent aq. NH3 / 1) DMF, reflux, 2.5 h; 2) DMF, dioxane 6: 32.5 g / SOCl2 / dimethylformamide / 3 h / 80 °C View Scheme
参考文献
Molecular crystals and liquid crystals, , vol. 88, # 1-4 p. 55 - 64
反应条件
1: AlCl3 / CH2Cl2 2: AlCl3 / 4 h / 45 - 50 °C 3: 80 percent NH2NH2, KOH / bis-(2-hydroxy-ethyl) ether / 1 h / Heating 4: 24.1 percent / AlCl3 / CH2Cl2 / 3 h / 0 °C 5: 88.9 percent / Br2, NaOH / dioxane / 5 h 6: 1) SOCl2; 2) 25 percent aq. NH3 / 1) DMF, reflux, 2.5 h; 2) DMF, dioxane 7: 32.5 g / SOCl2 / dimethylformamide / 3 h / 80 °C View Scheme
参考文献
Molecular crystals and liquid crystals, , vol. 88, # 1-4 p. 55 - 64
反应条件
1: 25percent aq. NH4OH 2: 64 percent / SOCl2, dimethylformamide / 1.5 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 19, p. 1479 - 1483
Zhurnal Organicheskoi Khimii, , vol. 19, # 8 p. 1669 - 1674
