3-(2-溴乙基)-1-甲基吲哚合成路线 （共 11 条）
参考文献
Abel, Ernesto; Maguire, Glenn E. M.; Murillo, Oscar; Suzuki, Iwao; De Wall, Stephen L.; Gokel, George W.
Journal of the American Chemical Society, 1999 , vol. 121, # 39 p. 9043 - 9052
反应条件
triphenylphosphine in acetonitrile
参考文献
Bristol-Myers Squibb Company
Patent: US4954502 A1, 1990 ;
反应条件
phosphorus tribromide in benzene
2 h; Heating;
参考文献
Atta-ur-Rahman; Sultana, Mumtaz; Hassan, Iltifat; Hasan, Naeem M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , p. 2093 - 2096
反应条件
1: 94 percent / sulphuric acid / 24 h / 25 °C
2: 88 percent / lithium aluminium hydride / diethyl ether / 1 h / 30 °C
3: 72.25 percent / phosphorus tribromide / benzene / 2 h / Heating
View Scheme
参考文献
Atta-ur-Rahman; Sultana, Mumtaz; Hassan, Iltifat; Hasan, Naeem M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , p. 2093 - 2096
反应条件
1: 88 percent / lithium aluminium hydride / diethyl ether / 1 h / 30 °C
2: 72.25 percent / phosphorus tribromide / benzene / 2 h / Heating
View Scheme
参考文献
Atta-ur-Rahman; Sultana, Mumtaz; Hassan, Iltifat; Hasan, Naeem M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , p. 2093 - 2096
反应条件
1: NaH / tetrahydrofuran / 24 h / 30 °C
2: H2SO4 / 21 h / 30 °C
3: LAH / diethyl ether / 2 h / 30 °C
4: PBr3 / benzene / 5 h / Heating
View Scheme
参考文献
Rahman, Atta-ur; Sultana, Mumtaz; Hassan, Iltifat
Tetrahedron Letters, 1983 , vol. 24, # 17 p. 1845 - 1848
反应条件
1: 58.2 g / sodium hydride / tetrahydrofuran / 1.) reflux, 5 min, 2.) room temperature, 0.5 h
2: 38.0 g / KOH, H2O / methanol / 1 h
3: PBr3
View Scheme
参考文献
Leeson, Paul D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2125 - 2128
反应条件
1: 55.3 g / AnalaR pyridine / 1 h / Ambient temperature
2: 58.2 g / sodium hydride / tetrahydrofuran / 1.) reflux, 5 min, 2.) room temperature, 0.5 h
3: 38.0 g / KOH, H2O / methanol / 1 h
4: PBr3
View Scheme
参考文献
Leeson, Paul D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2125 - 2128
反应条件
1: 38.0 g / KOH, H2O / methanol / 1 h
2: PBr3
View Scheme
参考文献
Leeson, Paul D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2125 - 2128
反应条件
1: 75 percent / ethyl acetate / 72 h / 120 °C
2: 60 percent / NaBH4, Et3N / methanol / 1 h / 0 °C
View Scheme
参考文献
Rahman, Atta-ur; Sultana, Mumtaz; Hassan, Iltifat
Tetrahedron Letters, 1983 , vol. 24, # 17 p. 1845 - 1848
