(2S)-2-戊基环氧乙烷合成路线 （共 17 条）
反应条件
sodium carbonate
T=20°C; 2 h;
参考文献
Garel, Laurent; Schlama, Thierry
Patent: US2007/4942 A1, 2007 ;
Location in patent: Page/Page column 7 ;
反应条件
tert.-butyl lithium in pentane
T=-30 - 20°C; 1 h;
参考文献
Lu, Shou-Fu; O'Yang, QinQin; Guo, Zhong-Wu; Yu, Biao; Hui, Yong-Zheng
Journal of Organic Chemistry, 1997 , vol. 62, # 24 p. 8400 - 8405
反应条件
1: With sodium tetrahydroborate in methanol
T=20°C; 1 h;
2: With water in methanol
3: With potassium hydroxide in ethanol
1 h; optical yield given as percent ee;
参考文献
Kang, Baldip; Mowat, Jeffrey; Pinter, Thomas; Britton, Robert
Organic Letters, 2009 , vol. 11, # 8 p. 1717 - 1720
反应条件
potassium hydroxide; hydrogen bromide
1.) glacial acetic acid, 0 deg C, 5 min, 2.) methanol, 15 min; Multistep reaction;
参考文献
Hoeyer, Thomas; Kjaer, Anders; Lykkesfeldt, Jens
Collection of Czechoslovak Chemical Communications, 1991 , vol. 56, # 5 p. 1042 - 1051
参考文献
Weijers; Botes; Van Dyk; De Bont
Tetrahedron Asymmetry, 1998 , vol. 9, # 3 p. 467 - 473
反应条件
hydrogen bromide; acetic acid; potassium pentanolate
1) 0 deg C, 30 min, 2) n-C5H11OH; Multistep reaction;
参考文献
Schmidt, Ulrich; Talbiersky, Joerg; Bartkowiak, Frank; Wild, Jochen
Angewandte Chemie, 1980 , vol. 92, # 3 p. 201 - 202
反应条件
1: m-chloroperoxybenzoic acid / CH2Cl2 / 0 °C
View Scheme
参考文献
Weijers; Botes; Van Dyk; De Bont
Tetrahedron Asymmetry, 1998 , vol. 9, # 3 p. 467 - 473
反应条件
1: 90 percent / pyridine, N,N-dimethyl-4-aminopyridine (DMAP) / CH2Cl2 / 4 h / Ambient temperature
3: 99 percent / K2CO3, H2O / methanol / 12 h / Ambient temperature
4: 1.) trimethyloxonium tetrafluoroborate, 2.) aq. NaOH / 1.) CH2Cl2, RT, 2 h, 2.) CH2Cl2, 2.5 h
View Scheme
参考文献
Haase, Bernhard; Schneider, Manfred P.
Tetrahedron: Asymmetry, 1993 , vol. 4, # 5 p. 1017 - 1026
反应条件
2: 99 percent / K2CO3, H2O / methanol / 12 h / Ambient temperature
3: 1.) trimethyloxonium tetrafluoroborate, 2.) aq. NaOH / 1.) CH2Cl2, RT, 2 h, 2.) CH2Cl2, 2.5 h
View Scheme
参考文献
Haase, Bernhard; Schneider, Manfred P.
Tetrahedron: Asymmetry, 1993 , vol. 4, # 5 p. 1017 - 1026
反应条件
1: 99 percent / K2CO3, H2O / methanol / 12 h / Ambient temperature
2: 1.) trimethyloxonium tetrafluoroborate, 2.) aq. NaOH / 1.) CH2Cl2, RT, 2 h, 2.) CH2Cl2, 2.5 h
View Scheme
参考文献
Haase, Bernhard; Schneider, Manfred P.
Tetrahedron: Asymmetry, 1993 , vol. 4, # 5 p. 1017 - 1026
