三苯基-(3,4,5-三甲氧基-苄基)-溴化膦合成路线 （共 26 条）
反应条件
1: NaH / benzene / 16 h / Ambient temperature 2: H2 / 10percent Pd/C / ethyl acetate / 4 h / 2068.6 Torr View Scheme
参考文献
Cushman, Mark; Nagarathnam, Dhanapalan; Gopal, D.; Chakraborti, Asit K.; Lin, Chii M.; Hamel, Ernest
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2579 - 2588
反应条件
1: 1.) butyllithium / 1.) THF, -23 deg C, 60 min, 2.) THF, a) -23 deg C, 4 h, b) RT, 14 h 2: 93 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.33 h 3: 94.4 percent / H2 / 10percent Pd/C / methanol; ethyl acetate / Ambient temperature View Scheme
参考文献
Pettit, George R.; Singh, Sheo Bux; Boyd, Michael R.; Hamel, Ernest; Pettit, Robin K.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1666 - 1672
反应条件
lithium methanolate in methanol; N,N-dimethyl-formamide T=90°C; 1 h; Title compound not separated from byproducts;
参考文献
Mervic, Miljenko; Ghera, Eugene
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4720 - 4725
反应条件
1: 3,4,5-Trimethoxybenzyltriphenylphosphonium Bromide With n-butyllithium in tetrahydrofuran; hexane T=0°C; Wittig type reaction; 2: 3,4,5-trimethoxy-benzyl alcohol With 4,4'-di-tert-butylbiphenyl; lithium; nickel dichloride in tetrahydrofuran; hexane Wittig type reaction; 24 h; Inert atmosphereReflux; 3: With 2,2'-azo-bisisobutyronitrile; diphenyldisulfane in tetrahydrofuran 8 h; Reflux;
参考文献
Alonso, Francisco; Riente, Paola; Yus, Miguel
European Journal of Organic Chemistry, 2009 , # 34 p. 6034 - 6042
反应条件
1: 3,4,5-Trimethoxybenzyltriphenylphosphonium Bromide With n-butyllithium in tetrahydrofuran; hexane T=0°C; Wittig type reaction; 2: 3,4,5-trimethoxy-benzyl alcohol With 4,4'-di-tert-butylbiphenyl; lithium; nickel dichloride in tetrahydrofuran; hexane Wittig type reaction; 24 h; Inert atmosphereReflux; optical yield given as percent de;
参考文献
Alonso, Francisco; Riente, Paola; Yus, Miguel
European Journal of Organic Chemistry, 2009 , # 34 p. 6034 - 6042
反应条件
sodium hydride in benzene 16 h; Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2579 - 2588
反应条件
1: 3,4,5-Trimethoxybenzyltriphenylphosphonium Bromide With n-butyllithium in tetrahydrofuran; hexane T=0°C; Wittig type reaction; 2: (4-methoxyphenyl)methanol With 4,4'-di-tert-butylbiphenyl; lithium; nickel dichloride in tetrahydrofuran; hexane Wittig type reaction; 12 h; Inert atmosphereReflux; optical yield given as percent de;
参考文献
Alonso, Francisco; Riente, Paola; Yus, Miguel
European Journal of Organic Chemistry, 2009 , # 34 p. 6034 - 6042
反应条件
1: 27 percent / NaH / benzene / 16 h / Ambient temperature 2: 80 percent / n-Bu4NF / tetrahydrofuran / 0.5 h / Ambient temperature View Scheme
参考文献
Cushman, Mark; Nagarathnam, Dhanapalan; Gopal, D.; Chakraborti, Asit K.; Lin, Chii M.; Hamel, Ernest
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2579 - 2588
反应条件
1: n-BuLi / tetrahydrofuran 2: (n-Bu)4NF / tetrahydrofuran View Scheme
参考文献
Guo, Xiaotao; Zhang, Dan; Yu, Zhifang; Liu, Tianzhen; Li, Dachang; Li, Chunbao
Journal of Chemical Research, 2011 , vol. 35, # 4 p. 229 - 230
反应条件
potassium carbonate in ethanol Wittig reaction; 8 h; RefluxInert atmosphere; optical yield given as percent de;
参考文献
Guo, Xiaotao; Zhang, Dan; Yu, Zhifang; Liu, Tianzhen; Li, Dachang; Li, Chunbao
Journal of Chemical Research, 2011 , vol. 35, # 4 p. 229 - 230
