1: 5-bromo-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]-1H-indol-2-ol With zinc; tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium(0) in N,N-dimethyl-formamide T=50°C; 0.0666667 h; 2: zinc cyanide in N,N-dimethyl-formamide T=50°C; 3 h; Product distribution / selectivity;

1: With iron; acetic acid T=60°C; 3 h; 2: With ammonia in methanol; dichloromethane Product distribution / selectivity;

triethylamine in acetic acid n-butyl ester T=90°C; Product distribution / selectivity;

1: 2-oxo-2,3-dihydro-indole-5-carbonitrile With sodium hydride in N,N-dimethyl-formamide 0.25 h; 2: N-(6-chloropyridin-3-ylmethyl)morpholine in N,N-dimethyl-formamide 1 h; Heating / reflux; Product distribution / selectivity;

[(t-Bu3P)PdBr]2; zinc in N,N-dimethyl-formamide T=40 - 50°C; 3 h; Inert atmosphereSchlenk techniqueLarge scale; Reagent/catalyst;