S-(+)-Alpha-3-(1-萘氧基)-1,2-环氧丙烷合成路线 （共 33 条）
反应条件
1: With lithium bromide in tetrahydrofuran
T=25°C;
2: With sulfuric acid in diethyl ether
T=25°C;
3: With potassium carbonate in methanol
T=0°C; 2 h;
参考文献
Sayyed, Iliyas A.; Thakur, Vinay V.; Nikalje, Milind D.; Dewkar, Gajanan K.; Kotkar; Sudalai
Tetrahedron, 2005 , vol. 61, # 11 p. 2831 - 2838
反应条件
1: 90 percent / K2CO3 / butan-2-one / 12 h / Heating
2: 47 percent / water / (R,R)-salen-Co(III)OAc complex / 24 h / 20 °C
View Scheme
参考文献
Subhas Bose; Narsimha Reddy; Chavhan, Sanjay W.
Synthesis, 2005 , # 14 art. no. Z03505SS, p. 2345 - 2348
反应条件
1: α-naphthol With sodium hydride in N,N-dimethyl-formamide; mineral oil
T=20°C; 0.5 h; Inert atmosphere;
2: (S)-glycidyl nosylate in N,N-dimethyl-formamide; mineral oil
T=60°C;
参考文献
Baker, Jillian G.; Adams, Luke A.; Salchow, Karolina; Mistry, Shailesh N.; Middleton, Richard J.; Hill, Stephen J.; Kellam, Barrie
Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6874 - 6887
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran; dimethyl sulfoxide
参考文献
Katsuki, Tsutomu
Tetrahedron Letters, 1984 , vol. 25, # 26 p. 2821 - 2822
反应条件
sodium hydroxide in methanol
T=0°C; 0.166667 h;
参考文献
Klunder; Soo Ko; Sharpless
Journal of Organic Chemistry, 1986 , vol. 51, # 19 p. 3710 - 3712
反应条件
1.1: (DHQD)2-PHAL; OsO4; K2CO3 / K2Fe(CN)6 / 2-methyl-propan-2-ol; H2O; toluene / 0 °C
2.1: SOCl2; Et3N / CH2Cl2 / 0 °C
3.1: 789 mg / RuCl3*3H2O; NaIO4 / acetonitrile; H2O / 0 °C
4.1: LiBr / tetrahydrofuran / 25 °C
4.2: aq. H2SO4 / diethyl ether / 25 °C
4.3: 80 percent / K2CO3 / methanol / 2 h / 0 °C
View Scheme
参考文献
Sayyed, Iliyas A.; Thakur, Vinay V.; Nikalje, Milind D.; Dewkar, Gajanan K.; Kotkar; Sudalai
Tetrahedron, 2005 , vol. 61, # 11 p. 2831 - 2838
反应条件
dichloro{μ-{{2,2'-{(1R,2R)-cyclohexane-1,2-diylbis[(nitrilo-κN)methylidyne]}bis[4,6-bis(1,1-dimethylethyl)phenolato-κO:κO]}(2-)}}dicobalt; water
T=20°C; 8 h; optical yield given as percent eeenantioselective reaction;
参考文献
Kawthekar, Rahul B.; Kim, Geon-Joong
Helvetica Chimica Acta, 2008 , vol. 91, # 2 p. 317 - 332
反应条件
trimethylsilylazide; β-cyclodextrin in ethanol; water
T=37°C; racemat resolution; 5 h; Title compound not separated from byproducts;
参考文献
Kamal, Ahmed; Arifuddin; Rao, Maddamsetty V.
Tetrahedron Asymmetry, 1999 , vol. 10, # 22 p. 4261 - 4264
反应条件
1: Et3N / 1 h / 80 - 90 °C
2: 20 percent aq. NaOH / propan-2-ol / Ambient temperature
View Scheme
参考文献
Bevinakatti; Banerji
Journal of Organic Chemistry, 1991 , vol. 56, # 18 p. 5372 - 5375
反应条件
sodium hydroxide in isopropyl alcohol
Ambient temperature;
参考文献
Bevinakatti; Banerji
Journal of Organic Chemistry, 1991 , vol. 56, # 18 p. 5372 - 5375
