S-(+)-Alpha-3-(1-萘氧基)-1,2-环氧丙烷合成路线 （共 33 条）
反应条件
1: water, NaOH / 52 h / Ambient temperature; Lipase PS "Amano", phosphate buffer (pH 7)
2: 20 percent aq. NaOH / propan-2-ol / Ambient temperature
View Scheme
参考文献
Bevinakatti; Banerji
Journal of Organic Chemistry, 1991 , vol. 56, # 18 p. 5372 - 5375
反应条件
Bacillus megaterium ECU1001 epoxide hydrolase in potassium phosphate buffer; dimethyl sulfoxide
T=30°C; pH=7; 2 h; Resolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Zhao, Jing; Chu, Yan-Yan; Li, Ai-Tao; Ju, Xin; Kong, Xu-Dong; Pan, Jiang; Tang, Yun; Xu, Jian-He
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 9 p. 1510 - 1518
反应条件
potassium carbonate in acetonitrile
Heating; Title compound not separated from byproducts.;
参考文献
Shivani; Pujala, Brahmam; Chakraborti, Asit K.
Journal of Organic Chemistry, 2007 , vol. 72, # 10 p. 3713 - 3722
反应条件
potassium carbonate in acetonitrile
Heating; Title compound not separated from byproducts.;
参考文献
Shivani; Pujala, Brahmam; Chakraborti, Asit K.
Journal of Organic Chemistry, 2007 , vol. 72, # 10 p. 3713 - 3722
反应条件
1.1: 789 mg / RuCl3*3H2O; NaIO4 / acetonitrile; H2O / 0 °C
2.1: LiBr / tetrahydrofuran / 25 °C
2.2: aq. H2SO4 / diethyl ether / 25 °C
2.3: 80 percent / K2CO3 / methanol / 2 h / 0 °C
View Scheme
参考文献
Sayyed, Iliyas A.; Thakur, Vinay V.; Nikalje, Milind D.; Dewkar, Gajanan K.; Kotkar; Sudalai
Tetrahedron, 2005 , vol. 61, # 11 p. 2831 - 2838
反应条件
1: sodium hydroxide / water / 5 h / 20 °C
2: Bacillus megaterium ECU1001 epoxide hydrolase / potassium phosphate buffer; dimethyl sulfoxide / 2 h / 30 °C / pH 7 / Resolution of racemate; Enzymatic reaction
View Scheme
参考文献
Zhao, Jing; Chu, Yan-Yan; Li, Ai-Tao; Ju, Xin; Kong, Xu-Dong; Pan, Jiang; Tang, Yun; Xu, Jian-He
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 9 p. 1510 - 1518
反应条件
1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C
2: Bacillus megaterium epoxide hydrolase / di-isopropyl ether; aq. phosphate buffer / 25 °C / pH 7 / |Enzymatic reaction
View Scheme
参考文献
Kong, Xu-Dong; Ma, Qian; Zhou, Jiahai; Zeng, Bu-Bing; Xu, Jian-He
Angewandte Chemie - International Edition, 2014 , vol. 53, # 26 p. 6641 - 6644
Angew. Chem., 2014 , p. 6759 - 6762,4
反应条件
in N,N-dimethyl-formamide
4 h;
参考文献
Klunder; Soo Ko; Sharpless
Journal of Organic Chemistry, 1986 , vol. 51, # 19 p. 3710 - 3712
反应条件
1: carbamic acid 1,1-dimethylethyl ester With chiral Co(III) polymeric salen complex in dichloromethane
0.166667 h;
2: [(1-naphthalenyloxy)methyl]oxirane in dichloromethane
16 h; enantioselective reaction;
参考文献
Kumar, Manish; Kureshy, Rukhsana I.; Shah, Arpan K.; Das, Anjan; Khan, Noor-Ul H.; Abdi, Sayed H. R.; Bajaj, Hari C.
Journal of Organic Chemistry, 2013 , vol. 78, # 18 p. 9076 - 9084
参考文献
Rama Rao; Gurjar; Joshi
Tetrahedron Asymmetry, 1990 , vol. 1, # 10 p. 697 - 698
