1: 7-bromo-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one With sodium hydride in tetrahydrofuran T=0°C; 1 h; 2: With di-4 morpholino-chlorophosphoramidate in tetrahydrofuran T=20°C; 2 h; 3: acetic acid hydrazide in tetrahydrofuran; butan-1-ol T=20°C; 0.166667 h;

1: 7-bromo-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one With sodium hydride in tetrahydrofuran T=0°C; 1 h; 2: With di-4 morpholino-chlorophosphoramidate in tetrahydrofuran T=0 - 20°C; 2 h; 3: acetic acid hydrazide in tetrahydrofuran; butan-1-ol T=20°C; 2.25 h; Heating / reflux;