N-[(1s)-1-[[[(5s)-5-[[(4-氨基苯基)磺酰基](2-甲基丙基)氨基]-6-羟基己基]氨基]羰基]-2,2-二苯基乙基]氨基甲酸甲酯合成路线 （共 8 条）
反应条件
1: 95 percent / HCl / ethanol / 20 °C
2: EDAC; HOBt / dimethylformamide
View Scheme
参考文献
Stranix, Brent R.; Lavallee, Jean-Francois; Sevigny, Guy; Yelle, Jocelyn; Perron, Valerie; LeBerre, Nicholas; Herbart, Dominik; Wu, Jinzi J.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 13 p. 3459 - 3462
反应条件
1: NaBH4 / ethanol / 6 h
2: 95 percent / HCl / ethanol / 20 °C
3: EDAC; HOBt / dimethylformamide
View Scheme
参考文献
Stranix, Brent R.; Lavallee, Jean-Francois; Sevigny, Guy; Yelle, Jocelyn; Perron, Valerie; LeBerre, Nicholas; Herbart, Dominik; Wu, Jinzi J.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 13 p. 3459 - 3462
反应条件
1: aq. K2CO3 / acetone
2: EDAC; HOBt / dimethylformamide
View Scheme
参考文献
Stranix, Brent R.; Lavallee, Jean-Francois; Sevigny, Guy; Yelle, Jocelyn; Perron, Valerie; LeBerre, Nicholas; Herbart, Dominik; Wu, Jinzi J.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 13 p. 3459 - 3462
反应条件
1: 88 percent / TEA / ethyl acetate
2: DMAP / acetonitrile
3: NaBH4 / ethanol / 6 h
4: 95 percent / HCl / ethanol / 20 °C
5: EDAC; HOBt / dimethylformamide
View Scheme
参考文献
Stranix, Brent R.; Lavallee, Jean-Francois; Sevigny, Guy; Yelle, Jocelyn; Perron, Valerie; LeBerre, Nicholas; Herbart, Dominik; Wu, Jinzi J.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 13 p. 3459 - 3462
反应条件
1: 89 percent / STAB / CH2Cl2
2: 88 percent / TEA / ethyl acetate
3: DMAP / acetonitrile
4: NaBH4 / ethanol / 6 h
5: 95 percent / HCl / ethanol / 20 °C
6: EDAC; HOBt / dimethylformamide
View Scheme
参考文献
Stranix, Brent R.; Lavallee, Jean-Francois; Sevigny, Guy; Yelle, Jocelyn; Perron, Valerie; LeBerre, Nicholas; Herbart, Dominik; Wu, Jinzi J.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 13 p. 3459 - 3462
反应条件
1: 88 percent / TEA / ethyl acetate
2: DMAP / acetonitrile
3: NaBH4 / ethanol / 6 h
4: 95 percent / HCl / ethanol / 20 °C
5: EDAC; HOBt / dimethylformamide
View Scheme
参考文献
Stranix, Brent R.; Lavallee, Jean-Francois; Sevigny, Guy; Yelle, Jocelyn; Perron, Valerie; LeBerre, Nicholas; Herbart, Dominik; Wu, Jinzi J.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 13 p. 3459 - 3462
反应条件
1: DMAP / acetonitrile
2: NaBH4 / ethanol / 6 h
3: 95 percent / HCl / ethanol / 20 °C
4: EDAC; HOBt / dimethylformamide
View Scheme
参考文献
Stranix, Brent R.; Lavallee, Jean-Francois; Sevigny, Guy; Yelle, Jocelyn; Perron, Valerie; LeBerre, Nicholas; Herbart, Dominik; Wu, Jinzi J.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 13 p. 3459 - 3462
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide
参考文献
Stranix, Brent R.; Lavallee, Jean-Francois; Sevigny, Guy; Yelle, Jocelyn; Perron, Valerie; LeBerre, Nicholas; Herbart, Dominik; Wu, Jinzi J.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 13 p. 3459 - 3462
