1-环己基-2-苯基-1-乙酮合成路线 （共 31 条）
参考文献
Wenus-Danilowa; Bolschuchin
Zhurnal Obshchei Khimii, 1939 , vol. 9, p. 975,982
Chem. Zentralbl., 1940 , vol. 111, # I p. 1190
反应条件
1: benzyl cyclohexyl ketone With sodium hydride in DMF (N,N-dimethyl-formamide) T=20°C; 1 h; 2: 2-bromoacetaldehyde diethyl acetal in DMF (N,N-dimethyl-formamide) T=20 - 80°C; 2 h;
参考文献
WO2003/106444 A1, ;
Page 32 ;
WO 03/106444 A1
反应条件
bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran
T=20°C; 1.5 h;
参考文献
Leonardi, Amedeo; Motta, Gianni; Riva, Carlo; Testa, Rodolfo
Patent: US2004/72822 A1, 2004 ;
Location in patent: Page/Page column 15 ;
US 20040072822 A1
反应条件
1: cyclohexanecarboxylic acid With 1,1'-carbonyldiimidazole in dichloromethane
T=0°C; 1 h;
2: With O,N-dimethyl-hydroxylamine hydrochloride; triethylamine in dichloromethane
T=20°C;
3: chloro(phenylmethyl)-magnesium With water; ammonium chloride
more than 3 stages;
参考文献
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA
Patent: WO2006/8556 A1, 2006 ;
Location in patent: Page/Page column 22 ;
反应条件
potassium dichromate; sulfuric acid; acetic acid in water; toluene
T=20°C; 19 h;
参考文献
Blakemore, Paul R.; Marsden, Stephen P.; Vater, Huw D.
Organic Letters, 2006 , vol. 8, # 4 p. 773 - 776
反应条件
in tetrahydrofuran; diethyl ether; water; ethyl acetate
参考文献
Godfrey, Alexander Glenn; Kohlman, Daniel Timothy; O'Toole, John Cunningham; Xu, Yao-Chang; Zhang, Tony Yantao
Patent: US2004/44009 A1, 2004 ;
US 20040044009 A1
反应条件
PhSeNa in ethanol
T=60°C; 2 h;
参考文献
Satoh, Tsuyoshi; Kaneko, Youhei; Izawa, Takao; Sakata, Kiichi; Yamakawa, Koji
Bulletin of the Chemical Society of Japan, 1985 , vol. 58, # 7 p. 1983 - 1990
反应条件
nickel in ethylene glycol dimethyl ether
T=85°C; 0.25 h;
参考文献
Inaba, Shin-ichi; Rieke, Reuben D.
Tetrahedron Letters, 1983 , vol. 24, # 24 p. 2451 - 2452
Title/Abstract Full Text View citing articles Show Details
Inaba, Shin-ichi; Rieke, Reuben D.
Journal of Organic Chemistry, 1985 , vol. 50, # 9 p. 1373 - 1381
反应条件
tetrakis(triphenylphosphine) palladium(0); zinc in ethylene glycol dimethyl ether
T=0 - 20°C;
参考文献
Hashimoto, Hiromasa; Maeda, Kimiya; Ozawa, Koichi; Haruta, Jun-Ichi; Wakitani, Korekiyo
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 1 p. 65 - 68
反应条件
1.1: 95 percent / I2 / CH2Cl2 / 22 h / 20 °C
2.1: iPrMgCl*LiCl / tetrahydrofuran / 1.5 h / -40 °C
2.2: 70 percent / tetrahydrofuran / 0.75 h / -40 - -15 °C
View Scheme
参考文献
Stoll, Armin H.; Krasovskiy, Arkady; Knochel, Paul
Angewandte Chemie - International Edition, 2006 , vol. 45, # 4 p. 606 - 609
