3-(4-硝基苯基)-2-丙炔-1-醇合成路线 （共 20 条）
反应条件
copper(l) iodide; triethylamine; PdCl2(PPh3) in 1-methyl-pyrrolidin-2-one; chloroform
Substitution;
参考文献
Suchy, Petr; Dvorak, Dalimil; Havelkova, Martina
Collection of Czechoslovak Chemical Communications, 1999 , vol. 64, # 1 p. 119 - 129
参考文献
Wake Forest University
Patent: US6242478 B1, 2001 ;
反应条件
ethanol; pyridinium p-toluenesulfonate
T=20°C;
参考文献
Maji, Manasi; Mallick, Dibyendu; Mondal, Sayantan; Anoop, Anakuthil; Bag, Subhendu Sekhar; Basak, Amit; Jemmis, Eluvathingal D.
Organic Letters, 2011 , vol. 13, # 5 p. 888 - 891
反应条件
1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / 2 h / 20 °C / Inert atmosphere
2: ethanol; pyridinium p-toluenesulfonate / 20 °C
View Scheme
参考文献
Maji, Manasi; Mallick, Dibyendu; Mondal, Sayantan; Anoop, Anakuthil; Bag, Subhendu Sekhar; Basak, Amit; Jemmis, Eluvathingal D.
Organic Letters, 2011 , vol. 13, # 5 p. 888 - 891
反应条件
(i) Py, (ii) aq. HCl; Multistep reaction;
参考文献
Harris,M.A. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1976 , p. 1612 - 1615
反应条件
1: With potassium tert-butylate; copper (II) acetate monohydrate; 1,3-bis(2,6-diisopropylphenyl)imidazolinium chloride; tert-butyl alcohol in toluene
T=25°C; 25 h; Inert atmosphere;
2: With tetrabutyl ammonium fluoride in tetrahydrofuran; toluene
T=0°C;
参考文献
Wang, Guang-Hui; Bin, Huai-Yu; Sun, Miao; Chen, Shu-Wei; Liu, Ji-Hong; Zhong, Chong-Min
Tetrahedron, 2014 , vol. 70, # 12 p. 2175 - 2179
反应条件
1: thionyl chloride / dichloromethane / 4 h / 0 - 40 °C
2: tetrakis(dimethylamino)ethylene / 3 h / -20 - 20 °C
View Scheme
参考文献
Roche, Manon; Terme, Thierry; Vanelle, Patrice
Molecules, 2013 , vol. 18, # 2 p. 1540 - 1548
反应条件
1: thionyl chloride / dichloromethane / 4 h / 0 - 40 °C
2: tetrakis(dimethylamino)ethylene / N,N-dimethyl-formamide / 3.5 h / -50 - 60 °C / |Inert atmosphere
View Scheme
参考文献
Roche, Manon; Terme, Thierry; Vanelle, Patrice
Molecules, 2013 , vol. 18, # 2 p. 1540 - 1548
反应条件
1: thionyl chloride / dichloromethane / 4 h / 0 - 40 °C
2: tetrakis(dimethylamino)ethylene / N,N-dimethyl-formamide / 3.5 h / -50 - 60 °C / |Inert atmosphere
View Scheme
参考文献
Roche, Manon; Terme, Thierry; Vanelle, Patrice
Molecules, 2013 , vol. 18, # 2 p. 1540 - 1548
反应条件
1: With carbon tetrabromide in dichloromethane
T=0°C; 0.166667 h;
2: With triphenylphosphine in dichloromethane
T=0 - 20°C;
参考文献
Okitsu, Takashi; Sato, Kana; Potewar, Taterao M.; Wada, Akimori
Journal of Organic Chemistry, 2011 , vol. 76, # 9 p. 3438 - 3449
